DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and hecw1b

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_021336549.1	Gene:	hecw1b / 563730	ZFINID:	ZDB-GENE-060503-2	Length:	1555	Species:	Danio rerio

Alignment Length:	652	Identity:	174/652 - (26%)
Similarity:	292/652 - (44%)	Gaps:	108/652 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 DEFGNSCLFDQNQSDEA-------LQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFP 432
            |..|.|...|.|.....       ||..::..:..|...:::|:........:|:....|:.|..
Zfish   961 DPQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRTRGVSLLAR 1025

  Fly   433 EPTCLRAVISYRDQQLPNGDFDIIVLSSSD---TTLVHKNI----------ASRKHNICYEAKLL 484
            ....|.|.|..:.||.|      :.|:.:|   ..|...||          .:|.|::  :.|:.
Zfish  1026 PGNSLVAAIRNQSQQEP------VPLAYNDKIVAFLRQPNIFEVLQERQPSFARNHSL--KDKVH 1082

  Fly   485 SIFGVSKNKPRKVLCYVGPKQNSLIFQVTI-KEMILKFIPKRIATFRLCPSTKFHFLPQL---VS 545
            .|......:..|:.|     ...|:..::: :|.|:.::|  :|:|.  |.  |:|.|:.   .|
Zfish  1083 HIRTEGTQRLEKLSC-----DADLVMLLSLFEEDIMSYVP--LASFH--PG--FNFSPRCSPGSS 1136

  Fly   546 QLHGPVFIIDDGAQPKIELASK-----DRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFH 605
            ..:.|.|:......|...|:.:     .|....|.:          ...|:.|...||   ||..
Zfish  1137 PQNSPGFLERTPLVPACCLSGESSPGTQRARAPAPY----------RRDFEAKLRNFY---RKLE 1188

  Fly   606 ASYYHE---KMALKVQREKILESSMKAVKGFSVSDWCGN-FEVTFQGEQGIDWGGLRREWFELVC 666
            |..|.:   |:.|.|:|:.:||.:...|..:|..:...| ..:||.||:|:|:.|..||:|.|:.
Zfish  1189 AKGYGQGPGKIKLIVRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLS 1253

  Fly   667 SALFDARGGLF-CTFHDKHQALVHPNPTRPAHLK--LKHFEFAGKMVGKCLFESALGGTYRQLVR 728
            ..||:...||| .:.:|.:...:.|   ..|.::  |:.|.|:|:::|..|.       ::.|:.
Zfish  1254 QELFNPYYGLFEYSANDTYTVQISP---MSAFVENHLEWFRFSGRILGLALI-------HQYLLD 1308

  Fly   729 ARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFV--EEMYDSSSGQL 791
            |.|:|.|...|:.|.......|..|.:.:.| ::::.:.|:  ||.|:|.|.  ||::    ||:
Zfish  1309 AFFTRPFYKALLRLPTDLSDLEYLDEEFHQS-LQWMKENDI--TDVLDLTFTVNEEVF----GQV 1366

  Fly   792 SKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELE 856
            ::. ||...|...:||...|.:|::.:.:.|:...|..:..:.::|...::...|:|:||..|||
Zfish  1367 TER-ELKSGGTNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELE 1430

  Fly   857 LLMCGTGEYSISDFKAHHIANGNSAEFRR-------VLAWFWAGVSNFSQTEMARLLQFTTGCSQ 914
            |::.||.|..::|::       |:.|:|.       |:.|||..|..|:..:..|||||.||.|.
Zfish  1431 LVIAGTAEIDLNDWR-------NNTEYRGGYHDGHIVIRWFWGAVERFNNEQRLRLLQFVTGTSS 1488

  Fly   915 LPPGGFQELN-----PQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            :|..||..|.     .:|.|.......:||.||||||:|.||.|.||....:.||:|:.|.|. |
Zfish  1489 VPYEGFTALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETST-F 1552

  Fly   975 GM 976
            |:
Zfish  1553 GL 1554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	117/377 (31%)
		HECTc	642..974	CDD:214523	109/348 (31%)
hecw1b	XP_021336549.1	HECW_N	73..192	CDD:318711
		C2_NEDL1-like	213..349	CDD:176073
		WW	771..803	CDD:197736
		WW	952..983	CDD:197736	5/21 (24%)
		HECTc	1223..1552	CDD:214523	110/354 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900