DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and smurf2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	370	Identity:	129/370 - (34%)
Similarity:	193/370 - (52%)	Gaps:	38/370 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   615 LKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCT 679
            ::|.||:|.|.|.:.|......|......|.|:||:|:|:||:.|||..|:...:.:...|||..
Zfish   412 IEVSREEIFEESYRQVMKMRPKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQY 476

  Fly   680 FHDKHQAL-VHP-NPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGL 742
            ..|....| ::| :...|.|  |.:|.|.|:::|..:|.    |.|   :...|:..|..||:|.
Zfish   477 SRDDIYTLQINPDSAVNPEH--LSYFHFVGRIMGMAVFH----GHY---IDGGFTLPFYKQLLGK 532

  Fly   743 RVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVT 807
            .:.....|..||||:.|.: :|||.|:  |..|:..|..|  .::.|::.:. ||.|||....||
Zfish   533 PITLDDMESVDPDLHNSLV-WILDNDI--TGVLDHTFCVE--HNAYGEIIQH-ELKPNGKSIPVT 591

  Fly   808 NATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKA 872
            ..||.:|:......|....::.:..:..||.|.:||.:||..|||.||||::||.|:..|:|:|:
Zfish   592 QDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKS 656

  Fly   873 -----HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQEL----NPQF- 927
                 |...:.|      ::.|||..|.::.:...||||||.||.|::|..||:.|    .|:.
Zfish   657 NTRLKHCTPDSN------IVKWFWRAVESYDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLF 715

  Fly   928 ---QITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISE 969
               ||.|:.  .|||.||||||::.:|.||||::....||.||.|
Zfish   716 TIHQIDAST--NNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEE 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	129/370 (35%)
		HECTc	642..974	CDD:214523	121/343 (35%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736
		WW	298..330	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375
		HECTc	410..762	CDD:238033	129/370 (35%)
		HECTc	437..762	CDD:214523	121/345 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810