DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Wwc2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_598552.2	Gene:	Wwc2 / 52357	MGIID:	1261872	Length:	1187	Species:	Mus musculus

Alignment Length:	588	Identity:	120/588 - (20%)
Similarity:	185/588 - (31%)	Gaps:	179/588 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 MGISSLSSCGDPERLP---------------ELPPLDEQRLQRAALHLQQKLIL----REWLKD- 118
            :|:.|.|:..:..||.               ||..||.:....|....::||:|    .|.||:
Mouse   294 IGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDGEAWPGALDIEKEKLMLINEKEELLKEL 358

  Fly   119 ------HRLQHHYQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQNLPTSKAQLDALKA 177
                  .|.|...:||.| |...||:.........|:.|.:..:| ...|:.|.....:...|..
Mouse   359 QFITPQKRSQEELERLEA-ERQHLEEELMAARGSPSRALTERLKL-EEKRKELLQKLEETTKLTT 421

  Fly   178 QLWSTVVKSSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPSLAPEARHSL-------LQYVTGKY 235
            .|:|.:...|..          .:|:|....:...|.::.||...:|.||       |.|
Mouse   422 SLYSQLQSLSSS----------TLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSSELYY----- 471

  Fly   236 LLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPICDTDH-----FFVEVTEG---TRKVVT 292
                           :|.|..|                 |||:     |.::...|   :..:.|
Mouse   472 ---------------SSQGDQM-----------------DTDYQYKLDFLLQEKGGYIPSGPITT 504

  Fly   293 ISE---LGSSTDPNNANIAKVKFTVR------TAGQYKISVLIGASHIA-----GSPF-LRSFLP 342
            |.|   :.|.:.|..:.:..|..|..      |.....::.|...|.::     |||. |.|..|
Mouse   505 IHENEVVKSPSQPGQSGLCGVGVTASSHTTPLTEASKSVASLSSRSSLSSLSPPGSPLVLDSVFP 569

  Fly   343 GAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAIYD------ 401
            |                   :...|..|..|.|  ...|...:..:|..| |...|:.|
Mouse   570 G-------------------SSHDTSPHQFPTD--FEDCELSRRFADVGL-GENQALLDSDSGGA 612

  Fly   402 ---------LHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVIS----------YRDQQ 447
                     |...|.|.|..........:..|..:.....:.|.:.|..|          |....
Mouse   613 SQPLLEDKGLSDCPGELLCEGATDVEKSLPKRRGLHLRGDKTTRVSAAASDESVAGDSGVYEASM 677

  Fly   448 LPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQV 512
            ...|:.:.:..|..|.|:|  ..|..:..:.|:.| .|.|.|...:.|.:..:..|..:.:.|:|
Mouse   678 KQPGEMEDVPYSEEDVTIV--ETAQVQIGLRYDTK-SSSFMVIIAQLRNLHAFSIPHSSKVYFRV 739

  Fly   513 TIKEMILKFIPKRI---ATFRLCPSTKFHFLPQLVSQLHGPVF---IIDDGAQPK---IEL--AS 566
            .:       :|...   ..||    ||.|  |...|.|:..||   :.....|.|   ::|  ||
Mouse   740 AL-------LPSSADVSCLFR----TKVH--PPTESVLYNDVFRVAVSQAALQQKTLRVDLCSAS 791

  Fly   567 KDR 569
            |.|
Mouse   792 KHR 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	20/119 (17%)
		Filamin	238..336	CDD:279024	20/119 (17%)
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
Wwc2	NP_598552.2	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..464		7/25 (28%)
		C2_Kibra	699..822	CDD:176062	28/110 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..849
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..963
		Phage_Nu1	<1088..>1146	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900