DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and UBR5

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_056986.2	Gene:	UBR5 / 51366	HGNCID:	16806	Length:	2799	Species:	Homo sapiens

Alignment Length:	1173	Identity:	224/1173 - (19%)
Similarity:	369/1173 - (31%)	Gaps:	461/1173 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KTFPT----------LKVKLCFGESMGISSLSSCGDPERLPELPPLDEQRLQRAALHLQQKLILR 113
            |..||          .:.:|.:|     |:|:|.|||.. |..|           ||..|....|
Human  1834 KLIPTWNWMVSIMDSTEAQLRYG-----SALASAGDPGH-PNHP-----------LHASQNSARR 1881

  Fly   114 EWLKDHRLQHHYQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQNLPTSKAQLDALKAQ 178
            |            |:.|.|.|||..   ||..|.:.:|        .|||.:.:::.  |.|...
Human  1882 E------------RMTAREEASLRT---LEGRRRATLL--------SARQGMMSARG--DFLNYA 1921

  Fly   179 LWSTVVKSSQHQDAWTWGGML-------VVSVSVAGLVTLAAMTQ------PSLAPEARHSLLQY 230
            |......:.:|.|...   :|       |..|..|.:..:.||.|      |.|..:....||:.
Human  1922 LSLMRSHNDEHSDVLP---VLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLEL 1983

  Fly   231 VTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISE 295
            .....                                       |::|   |..:.|.:..|:::
Human  1984 GIDNE---------------------------------------DSEH---ENDDDTNQSATLND 2006

  Fly   296 LGSSTDPNNANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLR-----SFLPGAIDARRSRFIRP 355
            ....:.|...                     |.:|    ||.|     :|| |.|..  :.|..|
Human  2007 KDDDSLPAET---------------------GQNH----PFFRRSDSMTFL-GCIPP--NPFEVP 2043

  Fly   356 ASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDK 420
            .:..|..|..|.|:....|.|                        ||.|.|.:.| ::...:..|
Human  2044 LAEAIPLADQPHLLQPNARKE------------------------DLFGRPSQGL-YSSSASSGK 2083

  Fly   421 VNSRVSV--TALFPEPT------CLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNI 477
            ....|:|  ..|...||      .|:.|::.:::|...|:...::...::::    ......|::
Human  2084 CLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESS----KPGPSAHDL 2144

  Fly   478 CYEAK--LLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFL 540
            ..:.|  ||:..|:::::        ||...|...|.:...|::.. ...:..:||.
Human  2145 AAQLKSSLLAEIGLTESE--------GPPLTSFRPQCSFMGMVISH-DMLLGRWRLS-------- 2192

  Fly   541 PQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFH 605
                .:|.|.||:.|.||:|                 ..:|..:||   |:.|:..|..|:.|..
Human  2193 ----LELFGRVFMEDVGAEP-----------------GSILTELGG---FEVKESKFRREMEKLR 2233

  Fly   606 ASYYHEKMALKVQREK--ILESSMKAVKGFSVSDWCG-------NFEVTFQGEQGIDWGGLRREW 661
             :.....::|:|.|::  :::.:|:.:.. .....|.       ..:|||:.|.| :..|:.|.:
Human  2234 -NQQSRDLSLEVDRDRDLLIQQTMRQLNN-HFGRRCATTPMAVHRVKVTFKDEPG-EGSGVARSF 2295

  Fly   662 FELVCSALFD----------------------------------------------ARGG----- 675
            :..:..|...                                              .|.|
Human  2296 YTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDR 2360

  Fly   676 ----------------------------------------------------------------- 675

Human  2361 DRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSP 2425

  Fly   676 ----LFCTFHDKHQALVH----------------------------------------------- 689
                |.....|..:|.|.
Human  2426 AQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDM 2490

  Fly   690 -------------------------PNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRA 729
                                     |.|.:....:|..|...|:::|.||.::       :|...
Human  2491 DLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQN-------ELCPI 2548

  Fly   730 RFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYIL---DTDLDAT-DTLELYF-VEEMYDSSSG 789
            ..:|..:..|:|.:|::..|...||.:|.|..:.||   .:|.||. ..::|.| ::...:...|
Human  2549 TLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGG 2613

  Fly   790 QLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENE 854
            |    :||||||....||.....:|:...|:.|:....:..:.:..|||..::|.|.|......:
Human  2614 Q----VELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAED 2674

  Fly   855 LELLMCGTGEYSIS---DFKAHHIANGNSAE----FRRVLAWFWAGVSNFSQTEMARLLQFTTGC 912
            ..||:.|.||.::.   .|.:.:..:|.:||    |:|   |||:.|...|.||...|:.|.|..
Human  2675 FRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKR---WFWSIVEKMSMTERQDLVYFWTSS 2736

  Fly   913 SQLPPG--GFQELNPQFQITAAPTFG-NLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            ..||..  |||   |...||..|... :||||:||.::|.:|.|.|.:..::.|||||.  ::.|
Human  2737 PSLPASEEGFQ---PMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK--TKNF 2796

  Fly   975 GMV 977
            |.|
Human  2797 GFV 2799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	8/97 (8%)
		Filamin	238..336	CDD:279024	8/97 (8%)
		HECTc	615..975	CDD:238033	108/575 (19%)
		HECTc	642..974	CDD:214523	103/538 (19%)
UBR5	NP_056986.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..175
		CUE_UBR5	184..230	CDD:270606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		ZnF_UBR1	1177..1244	CDD:197698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1515..1740
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1859..1890		15/54 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1984..2021		8/103 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2117..2142		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2392		2/68 (3%)
		PolyA	2389..2452	CDD:197769	4/62 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2493		0/19 (0%)
		HECTc	2501..2796	CDD:214523	89/313 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900