Protein Alignment CG4238 and HERC5

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: XP_011530324.2
• Gene: HERC5 / 51191
• HGNCID: 24368
• Length: 1100
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 129/631 - (20%)
• Similarity: 236/631 - (37%)
• Gaps: 168/631 - (26%)

  Fly   422 NSRVSVTALFPEPTCL-----------RAVISYRD--------QQLPNGDFDIIVLSSSDTTLVH 467
            :::..:..:|..|.||           ..:..|.|        ::|...|:    :::..||.:.
Human   561 STKREIQEIFSSPACLTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDW----ITNMITTCLK 621

  Fly   468 KNIASRK--HNICYEAKLLSIFGVSKNKP---------------RKVLCYVGPKQNSLIFQ---V 512
            .|:..|.  |:...||  |.||.:....|               .||:|.:. .|:||:.:   .
Human   622 DNLLKRLPFHSPPQEA--LEIFFLLPECPMMHISNNWESLVVPFAKVVCKMS-DQSSLVLEEYWA 683

  Fly   513 TIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFT 577
            |::|.....:.:...|..:|....:.                        |.|.::.|:.|
Human   684 TLQESTFSKLVQMFKTAVICQLDYWD------------------------ESAEENGNVQA---- 720

  Fly   578 HFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHE--------------KMALK------VQREKI 622
              ||:.:                 :|.|.|..|:              :.||:      |:|..:
Human   721 --LLEML-----------------KKLHRSKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHL 766

  Fly   623 LESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQAL 687
            :|..:..:..|...|......|:|.||.|.|.||:::|:|..:.:.:.....|:|
Human   767 IEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMF---------- 821

  Fly   688 VHPN-------PTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVH 745
            ::|.       |.:|...|.::| |.|.:.|..||..       .:....|..:...:|:.....
Human   822 MYPEGASCMWFPVKPKFEKKRYF-FFGVLCGLSLFNC-------NVANLPFPLALFKKLLDQMPS 878

  Fly   746 YKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVE-----EMYDSSSGQLSKTIELIPNGAKTR 805
            .:..::..|||. ..::.:||.:.|..:  |::::.     :..|::         |||||:...
Human   879 LEDLKELSPDLG-KNLQTLLDDEGDNFE--EVFYIHFNVHWDRNDTN---------LIPNGSSIT 931

  Fly   806 VTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDF 870
            |....|..|:.........::||...:.|.:|...:..::::.:|...||:.::.|..:|....|
Human   932 VNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTF 996

  Fly   871 K--AHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQIT-AA 932
            :  |.:....||:  ...:..||......:..|..:.|.|.||..:|.   .::|| ..:|| ..
Human   997 EKNARYEPGYNSS--HPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQ---MKDLN-NMKITFCC 1055

  Fly   933 PTFGNLP---TAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFG 975
            |...|..   .|.|||:.|.||.|.:.|..|::|..||: .:.|||
Human  1056 PESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAIN-NNRGFG 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	87/383 (23%)
		HECTc	642..974	CDD:214523	80/349 (23%)
HERC5	XP_011530324.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810