DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4238 and ASCC1

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_001185728.1 Gene:ASCC1 / 51008 HGNCID:24268 Length:400 Species:Homo sapiens


Alignment Length:447 Identity:82/447 - (18%)
Similarity:135/447 - (30%) Gaps:192/447 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 SYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNIC-YEAKLLSIFGVSKNKPRKVLCYVGPKQ 505
            :|..:|.|.|....:...|....|:|.|.:    |.| ::...|....:...|.|.::...|..:
Human    49 AYEVEQTPQGFRSTLRAPSLLYNLIHLNTS----NDCGFQKITLDCQNIYTWKSRHIVGKRGDTR 109

  Fly   506 NSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRN 570
            ..:  ::..|..|  .|||                               .|...:|.:..:.||
Human   110 KKI--EMETKTSI--SIPK-------------------------------PGQDGEIVITGQHRN 139

  Fly   571 --IIAATFTHFLLKNIGGSETFKDKQD------FFYHEVRKFHASYYHEKMALKVQREKILESSM 627
              |.|.|....||      :||:.||.      ||.:||..       ::..|:.|.|.:.:.||
Human   140 GVISARTRIDVLL------DTFRRKQPFTHFLAFFLNEVEV-------QEGFLRFQEEVLAKCSM 191

  Fly   628 KAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNP 692
                                 :.|:|             |::|.                   ||
Human   192 ---------------------DHGVD-------------SSIFQ-------------------NP 203

  Fly   693 TRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIG---LRVHYKYFE--QD 752
             :..||.:      |.:|  .|.|..:..|...|.:.:  ..|:..:.|   |.|.....|  .|
Human   204 -KKLHLTI------GMLV--LLSEEEIQQTCEMLQQCK--EEFINDISGGKPLEVEMAGIEYMND 257

  Fly   753 DP---DLYLSKIKY------------------------------------ILDT----DLDATDT 774
            ||   |:..:|:..                                    :::|    |.:|...
Human   258 DPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGR 322

  Fly   775 LELYFVEEMY-----DSSSGQ-LSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCN 825
            ..||..|..|     :|..|: :.|:..|:|           :.:|.||::..  ||
Human   323 YNLYTAEGKYIFKERESFDGRNILKSFALLP-----------RLEYNDAISAH--CN 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720
Filamin 238..336 CDD:279024
HECTc 615..975 CDD:238033 46/265 (17%)
HECTc 642..974 CDD:214523 41/238 (17%)
ASCC1NP_001185728.1 Required for interaction with ASCC3. /evidence=ECO:0000269|PubMed:29997253 1..53 1/3 (33%)
vigilin_like_KH 99..148 CDD:239087 14/83 (17%)
PLN00108 157..370 CDD:177724 52/294 (18%)
AKAP7_NLS 161..349 CDD:287446 43/258 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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