DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Magi1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_038964101.1	Gene:	Magi1 / 500261	RGDID:	1586025	Length:	1491	Species:	Rattus norvegicus

Alignment Length:	917	Identity:	158/917 - (17%)
Similarity:	273/917 - (29%)	Gaps:	349/917 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 GQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSCL 382
            |:..::||.||.| ...|::     ||:.|..:            ||.|         ..|....
  Rat    26 GELGVTVLGGAEH-GEFPYV-----GAVAAAEA------------AGLP---------GGGEGPK 63

  Fly   383 FDQNQSDEALQGYQVA---IYDLHGVPVEKLQHAIVFAYDKVNSRVS------VTALFPE----- 433
            ..:.:....:||.:|:   .||:.|| ::..:.|:.|...:...|::      :...|.:
  Rat    64 LAEGELLLEVQGVRVSGLPRYDVLGV-IDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDH 127

  Fly   434 ---------------PTCLRAVISYRDQQLPNGDFDIIV------LSSSDTTLVHKNIASRKHN- 476
                           |...|   |.|:.::|..|:..:.      |..|.|.|   .:.:.:.|
  Rat   128 ELQQTIRDNLYRHAVPCTTR---SPREGEVPGVDYSFLTVKEFLDLEQSGTLL---EVGTYEGNY 186

  Fly   477 ---------------ICYEAKLLSIFGVSKNKPRKVLCY-----VG------------PKQNSLI 509
                           |..:|......|..::.|::...|     .|            |:.||..
  Rat   187 YGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHTENEEEEDVPEMNSSF 251

  Fly   510 F-------QVTIKEMILKFI-PKRIATFRLCPSTKF-HFLP--------------QLVSQLHGPV 551
            .       :.|::|..|..: ...:|.....||.|| .:||              ::....:|.|
  Rat   252 TADSGDQDEPTLQEATLPPVNSSALAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEV 316

  Fly   552 FIIDDGA--------------QPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVR 602
            :.||...              |..:|....|...:........|:...|.|..:|.....|: |.
  Rat   317 YFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEEGVHTEELDSELELPAGWEKIEDPVYGVYY-VD 380

  Fly   603 KFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCS 667
            ..:....:|...|:.:|::.||...:              :...|.:..........||.|
  Rat   381 HINRKTQYENPVLEAKRKRQLEQQQQ--------------QQQHQQQPQQPQPPQPEEWTE---- 427

  Fly   668 ALFDARGGLFCTFHDKHQALV----------HPNPTRPAHLKLKHF------EFAGKMVGKCLFE 716
                           .|.::|          :|.|.|.|.|:.|.|      |..||.:...|.:
  Rat   428 ---------------DHASVVPPVAPSHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRK 477

  Fly   717 SA------------------------------------------------LGGTYRQLVRARFSR 733
            |:                                                ||.|:.|:|:. |..
  Rat   478 SSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI-FQS 541

  Fly   734 SFLAQLIGLRVHYKY---FEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTI 795
            ..:...:.|.:...|   |:.|||:..|.....|||.:....:..|.|.....:.|.:|::|...
  Rat   542 IPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSNMK 606

  Fly   796 ELIPNGAKTRVTNATKNQYLDALA-------QQRLC-----------------------NNVKDE 830
            :..|:......:|::.....|.::       |..|.                       ..||..
  Rat   607 DARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQI 671

  Fly   831 VDS-FLKGL-------------------NSIIPDNLLSIFDENELELLMCGTG------------ 863
            ||| ..:||                   |.:: |.|:.....:|:.||:...|
  Rat   672 VDSPRCRGLKEGDLIVEVNKRNVQALTHNQVV-DMLIECPKGSEVTLLVQRGGLPVPKKSPKSQP 735

  Fly   864 ----------EYSISDFKAHHIAN-GNSAEFRRVLAWF-WAGVSNFSQTE--------------M 902
                      ::|:|..::.|.|: .:||:   ||..: .|.|....||:              .
  Rat   736 LERKDSQNSSQHSVSSLRSLHTASPSHSAQ---VLPEYPPADVPAPDQTDSSGQKKPDPFKIWAQ 797

  Fly   903 ARLLQFTTGCSQLPPGGFQELNPQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAI 967
            :|.:......|..|..|..:.....:|.:           |.|.:..:|||:     |:.:.|..
  Rat   798 SRSMYENRPMSPSPASGLSKGERDREINS-----------TNFGECQIPDYQ-----EQDIFLWR 846

  Fly   968 SEGSEGF 974
            .|...||
  Rat   847 KETGFGF 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	6/17 (35%)
		Filamin	238..336	CDD:279024	6/17 (35%)
		HECTc	615..975	CDD:238033	89/515 (17%)
		HECTc	642..974	CDD:214523	83/486 (17%)
Magi1	XP_038964101.1	NK	122..293	CDD:418433	29/176 (16%)
		WW	302..331	CDD:395320	4/28 (14%)
		WW	362..393	CDD:197736	6/31 (19%)
		PDZ	469..555	CDD:214570	10/86 (12%)
		PDZ	640..723	CDD:214570	14/83 (17%)
		MAGI_u5	724..806	CDD:406953	13/84 (15%)
		PDZ_signaling	847..922	CDD:238492	3/7 (43%)
		PDZ_signaling	996..1091	CDD:238492
		PDZ	1152..1234	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900