Protein Alignment CG4238 and Wwc2

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001102581.1
• Gene: Wwc2 / 498630
• RGDID: 1559427
• Length: 1194
• Species: Rattus norvegicus
• Alignment Length: 578
• Identity: 123/578 - (21%)
• Similarity: 193/578 - (33%)
• Gaps: 173/578 - (29%)

  Fly    89 PELPPLDE-QRLQRAALHLQQKLI---------LREWLKDHRLQHHYQRLL--AVEVASLEDVYW 141
            |:....|| :||:.....|:::|:         |.|.||   |:...:.||  ..|...|....:
  Rat   363 PQKRTQDELERLEAERQRLEEELVAARGLPSRALAERLK---LEEKRKELLQKLEETTKLTTYLY 424

  Fly   142 -----LEDSRASKILGKDWQLWSGARQNLPT-SKAQLDALKAQLWSTVVKSSQHQDAWT------ 194
                 |..|..|...|......:.:|.:|.| |:..|::|.:   |.:..|||.....|
  Rat   425 SQLKSLSSSTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSS---SDLYYSSQGDQMDTDYQYKL 486

  Fly   195 ------WGGML-------------VVSVS------VAGLVTLAAMTQPSL--APEARHSLLQYVT 232
                  .||.:             |.|.|      :.||...|....|.|  |.::..||....:
  Rat   487 DFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSGLCGLGVAATSHTPPLTEASKSVTSLSSRSS 551

  Fly   233 GKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPI------CDTDHFFVEVTEGTRKVV 291
            ...|.|....:..|...|.|...|            .|:..      |:....|.::..|..:|:
  Rat   552 LSSLSPPGSPLVLDSTFPGSSHDT------------SPHQFTADLEDCELSRHFADIGLGENQVL 604

  Fly   292 TISELGSSTDPNNANIAKVKFTVRTAG-QYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRP 355
            ..|:.|.   |:.:.:........|.| .|:           ||..:...||    .||...:|.
  Rat   605 LDSDSGG---PSQSLLEDKDLDECTGGLLYE-----------GSADVEKSLP----KRRGLHLRG 651

  Fly   356 ASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQG----YQVAIY---DLHGVP------- 406
            ..|....|.|                      |||::.|    |:.::.   ::..:|
  Rat   652 DKTARVSAAA----------------------SDESVAGDSGVYEASVKQPGEIEDIPYREEDVT 694

  Fly   407 -VEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGD---FDIIVL-SSSDT--- 463
             ||..|..|...||..:|...|..     ..||.:.::   .:|:..   |.:.|| ||:|.
  Rat   695 IVETAQVQIGLRYDTKSSSFMVII-----AQLRNLHAF---SIPHSSKVYFRVAVLPSSADVSCL 751

  Fly   464 --TLVHKNIASRKHN---------ICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEM 517
              |.||....|..:|         :..:.|.|.:...|.:|.|:..|..| .|.||.......|:
  Rat   752 FRTKVHPPTESVLYNDVFRVAISQVVLQQKTLRVDLCSVSKRRREECLAG-TQISLADLPFSNEI 815

  Fly   518 ILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQ-PKIELASKDRNIIAA 574
            .:.:       :.|.||.:   :|....:..|.    ..||| |:..|.|.|.:.::|
  Rat   816 FMLW-------YNLLPSKQ---IPCKKKEEGGG----QPGAQSPQPALDSADLDAVSA 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	18/104 (17%)
		Filamin	238..336	CDD:279024	18/104 (17%)
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
Wwc2	NP_001102581.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792	6/21 (29%)
		YlqD	351..>420	CDD:287979	15/59 (25%)
		C2_Kibra	699..822	CDD:176062	31/138 (22%)
		Phage_Nu1	<1095..>1153	CDD:294991

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900