DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and arel1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001011393.1	Gene:	arel1 / 496863	XenbaseID:	XB-GENE-5852856	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	386/820 - (47%)
Similarity:	515/820 - (62%)	Gaps:	61/820 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 GGMLVVSVSVAGLVTLAA-----MTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGG 255
            |.|.|:.:::..|..|::     ......|..|..::..||.||||.|.:|.|.||||:|..||.
Frog    10 GLMCVLWITIKFLCELSSRVFTFWNHEGRARGAERNIYNYVRGKYLDPHSCHVSWDWKEPCEVGQ 74

  Fly   256 TMCFVVRFFQRNGQPYPICD--TDHFFVEVTEGTRKV-VTISELGSSTDPNNANIAKVKFTVRTA 317
            :|||.|..|.|||.|:|:..  |....:..||...:| :|:..|..||    .|:.||.||||.:
Frog    75 SMCFRVHLFYRNGDPFPLTASVTPKIRISHTELDLEVPITLEVLQDST----RNVMKVAFTVRKS 135

  Fly   318 GQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSCL 382
            |:|:|::.||..:|..||:.:.|.|||:...:::.:...||::...|....:.:.|||::||
Frog   136 GRYQINISIGGLNIGHSPYYKIFSPGAVVPSKTQIVSHFSTLVLKCGEQHTLQVVPRDQYGN--- 197

  Fly   383 FDQNQSDEALQGYQVAIYDLH--GVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRD 445
             ..:.|.:.|:.|.:.:.:|.  ||....||   |.......:||.:.....:..|.:|.:.::.
Frog   198 -HTSDSLKDLESYILTLSELGVVGVADGCLQ---VSVCSGSQNRVLLHLALLQTGCFQATLRFQG 258

  Fly   446 QQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLL------SIFGVSKN------------ 492
            ..:.||:|.||||:..:.|:|..|::.....:.:|..|.      :|.|..::
Frog   259 LPINNGNFQIIVLTDGEKTIVDNNVSRSGVGVFFEGYLYPPSSSPNIPGQHRSSSTSNDEESNAD 323

  Fly   493 --------KPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHG 549
                    ||:||..|:.||      |:::||..|:.||.|:.|||:||.|||.:||.  ..|||
Frog   324 GHTVDRLKKPKKVYFYITPK------QLSVKEFYLRIIPWRLFTFRVCPGTKFLYLPP--DPLHG 380

  Fly   550 PVFI-IDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHEKM 613
            .:.: :|||.||.||::.|||||:|||||.||..||||||||:||..||..|:|:.|......|:
Frog   381 LLSLQVDDGLQPPIEISCKDRNIMAATFTRFLHLNIGGSETFQDKVTFFQKELRQIHCKKTRCKV 445

  Fly   614 ALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFC 678
            .|||.|..:||||::|.:.||.||||.||||.||.|:.:||||.|||||||:|..|||....||.
Frog   446 TLKVNRHSLLESSLRATRNFSASDWCKNFEVVFQDEEALDWGGPRREWFELICKTLFDTNNQLFI 510

  Fly   679 TFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLR 743
            .|.|.:|.||||||.||.::::|.:||||::||||||||:|||...|||||||:||||||:||||
Frog   511 RFSDSNQGLVHPNPCRPPNIRVKLYEFAGRVVGKCLFESSLGGGCEQLVRARFTRSFLAQIIGLR 575

  Fly   744 VHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTN 808
            :||||||.||||.:.:|::|||..|:  .|| ||.|.||.| ..:|||.|.:||||.|::..|||
Frog   576 MHYKYFETDDPDFFQTKVQYILTNDV--IDT-ELSFAEEKY-GRAGQLEKVVELIPGGSQILVTN 636

  Fly   809 ATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAH 873
            ..|..||:.||..||.|.|::|||.||||||.::|||||.|||||||||||||||..::.||:||
Frog   637 ENKVYYLNLLANHRLSNQVREEVDHFLKGLNELVPDNLLGIFDENELELLMCGTGHIAVQDFQAH 701

  Fly   874 HIANGNSAEFR-RVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAPTFGN 937
            .:..|.|..|| :|::||||.||:.:|.|:|||||||||.||||||||..|:|.|||..:||.|.
Frog   702 AVVIGGSWHFREKVMSWFWAVVSSLTQEELARLLQFTTGSSQLPPGGFAALSPSFQIIGSPTHGT 766

  Fly   938 LPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            ||||||||||||||.|:|||:..|.|.||||||.|||||:
Frog   767 LPTAHTCFNQLCLPTYDSYEEMHKMLKLAISEGCEGFGML 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	42/100 (42%)
		Filamin	238..336	CDD:279024	42/100 (42%)
		HECTc	615..975	CDD:238033	226/360 (63%)
		HECTc	642..974	CDD:214523	209/332 (63%)
arel1	NP_001011393.1	Filamin	56..153	CDD:366210	41/100 (41%)
arel1	NP_001011393.1	HECTc	447..804	CDD:238033	226/360 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I740
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8885
Inparanoid	1	1.050	701	1.000	Inparanoid score	I655
OMA	1	1.010	-	-		QHG49700
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	1	1.000	-	-		FOG0008343
OrthoInspector	1	1.000	-	-		oto104543
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4924
SonicParanoid	1	1.000	-	-		X6322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110