DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and hyd

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster

Alignment Length:	1022	Identity:	208/1022 - (20%)
Similarity:	359/1022 - (35%)	Gaps:	300/1022 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MLVSHINVGGVMHAATGGKTFPTLKVKLCFGESMGISSLSSCGDPERLPELPPLDEQRL------ 99
            ::.::.|..|..:...||..|.....:|.|..|:..:        ||:.|..|:|..:.
  Fly  2081 LVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRN--------ERVYETVPIDSSKTGDGNVT 2137

  Fly   100 --------QRAALHLQQKLILREWLKDHR----LQHHYQRLLAVEVASLEDVYWLEDSRASKILG 152
                    ....:.|::|....:: |.|:    .|..|::::.:|.         :||
  Fly  2138 NKAEGSTDSNIYVQLKKKQGSDDF-KSHKEADGNQSKYEKVVLMET---------DDS------- 2185

  Fly   153 KDWQLWSGARQNLPTSKAQLDALKAQLWSTVVKSSQHQDAWTWGGMLVVSVSVA----GLVTLA- 212
                        ||::....:||.|.....::..::            .|||.|    .::.||
  Fly  2186 ------------LPSTSKSTEALMATRPEVIIAPNK------------ASVSPATAARSVIVLAG 2226

  Fly   213 --------------AMTQPSLAPEAR-HSLLQYVTGKYLL--PANCKVQWDWKDPASVGGTMCFV 260
                          :.:..|.|.:|: .:..|..|..:||  ||.              |:
  Fly  2227 GSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPAR--------------GS---- 2273

  Fly   261 VRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISVL 325
             :|:|.|                         .|||.|.    |..:::.|.|:...|:..:..
  Fly  2274 -QFYQSN-------------------------FSELPSW----NFLLSRWKLTLDLFGRVFMDD- 2307

  Fly   326 IGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIE------PRDEFGNSCLFD 384
            :|..|.:..|.||.|     ..:..||.|               |:|      .||..  .|..:
  Fly  2308 VGMEHGSVLPELRGF-----PVKEMRFRR---------------HMEKLRNGQQRDLV--LCKLE 2350

  Fly   385 QNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEP------------TCL 437
            :|:....:|.:: .:....|....::|..|.|      :||.|| ...||            :..
  Fly  2351 RNRESLIVQTFK-ELNTQFGNQSRRIQPPITF------NRVKVT-FKDEPGEGSGVARSFYTSIA 2407

  Fly   438 RAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVLCYVG 502
            .|:::  ..::||       |.|......|.     |:.:.:.:.|.|......::.:..|...|
  Fly  2408 EALLA--SAKIPN-------LESVQVGTNHS-----KYVVPFSSILRSRTVSGSSRDQSTLQRRG 2458

  Fly   503 PKQNSLIFQVTIKEM------ILKFIPKRIATFRLCPSTKFHF---LPQLVSQLHGPVFIIDDGA 558
              .||.|...:.:|.      ...:.|...:......|...|.   |.|:..:|:..:..|:...
  Fly  2459 --SNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTH 2521

  Fly   559 QPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHEKMALKVQREKIL 623
            .|||      ..::....|..||..|...||.:.|            .:...|.:..|.:.|...
  Fly  2522 APKI------TGMLLEIPTPQLLSVISSDETLRQK------------VNEAIEIITFKQKSETSA 2568

  Fly   624 ESSM--KAVKGFSVSDWCGNFEVTF--QGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKH 684
            :||.  |:.....|.....:.|..|  .|::|                 .:..|.| |.:|.
  Fly  2569 QSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRG-----------------FYTPRQG-FASFE--- 2612

  Fly   685 QALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYF 749
                          ::..|...|:::|.||.::.|...:.|       |..|..::|.::.:...
  Fly  2613 --------------RINAFRNIGRLIGLCLLQNELLPLFLQ-------RHVLKYILGRKIKFHDL 2656

  Fly   750 EQDDPDLYLSKIKYILDTDL----DATDTLELYFV-EEMYDSSSGQLSKTIELIPNGAKTRVTNA 809
            ...||.||.|..:.|.:...    :..:.:||.|| :.|.:...|..    ||||.|....||::
  Fly  2657 AFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNR----ELIPGGRDVAVTSS 2717

  Fly   810 TKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHH 874
            ...:|:....:.||..:.:..:::...|:..::|||.:......:|.||:.|.|:.::|...::.
  Fly  2718 NIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYT 2782

  Fly   875 IANGNSAE-------FRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPG--GFQELNPQFQIT 930
            ..|..|:|       |::   |||:.|...:..|...|:.|.||...||..  |||.| |...|.
  Fly  2783 TFNDESSEGPDKLLKFKK---WFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVTIR 2843

  Fly   931 AAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            .|.. .:||||:||.::|.:|.|.|.......:|:||.  |:.||.|
  Fly  2844 PADD-SHLPTANTCISRLYIPLYSSKSILRSKMLMAIK--SKNFGFV 2887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	16/97 (16%)
		Filamin	238..336	CDD:279024	16/97 (16%)
		HECTc	615..975	CDD:238033	92/377 (24%)
		HECTc	642..974	CDD:214523	86/347 (25%)
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	16/80 (20%)
		HECTc	2589..2885	CDD:238033	86/348 (25%)
		HECTc	2589..2884	CDD:214523	86/347 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830