DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Nedd4

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	145/414 - (35%)
Similarity:	216/414 - (52%)	Gaps:	43/414 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   583 NIGG-----SETFKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSD----- 637
            ||.|     |..:|.|.::|...:||  .:....|..::::|..|||.|.:.:...:.:|
  Fly   617 NIAGQAVPYSRDYKQKYEYFKSHIRK--PTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTK 679

  Fly   638 -WCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKL 700
             |     |.|:||.|:|:|||.||||.|:...:|:...||| .:..|.:...::..........|
  Fly   680 LW-----VEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHL 739

  Fly   701 KHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYIL 765
            .:|:|.|::.|..::       :.:|:.|.|.|.|...::...:..|..|..|.: |.:.:.:|.
  Fly   740 SYFKFIGRIAGMAVY-------HGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTE-YYNSLMWIK 796

  Fly   766 DTDLDATDTLELYFV--EEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVK 828
            :.|   ...|||.|.  |:::    ||.|:. ||.|.||...|||..|::|:..:.:.|....||
  Fly   797 END---PRILELTFCLDEDVF----GQKSQH-ELKPGGANIDVTNENKDEYIKLVIEWRFVARVK 853

  Fly   829 DEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAG 893
            :::.|||.|..||||.||:.||||:||||||||.....:.|::.:.:..|:......::.|||..
  Fly   854 EQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRA 918

  Fly   894 VSNFSQTEMARLLQFTTGCSQLPPGGFQEL----NPQ-FQITAAPTFGNLPTAHTCFNQLCLPDY 953
            |.:||....:|||||.||.|::|..||:||    .|| |.|....|..|.|.||||||:|.||.|
  Fly   919 VLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPY 983

  Fly   954 ESYEQFEKSLLLAISEGSEGFGMV 977
            |.|.|.:..|:.|| |||:||..|
  Fly   984 EGYLQLKDKLIKAI-EGSQGFAGV 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	133/373 (36%)
		HECTc	642..974	CDD:214523	125/339 (37%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	132/374 (35%)
		HECTc	674..1003	CDD:214523	127/350 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840