DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Ufd4

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	1070	Identity:	216/1070 - (20%)
Similarity:	352/1070 - (32%)	Gaps:	389/1070 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 VSVSVAGLVTLAAMTQPSLAPEARHS-LLQ--------------YVTGKYLLPANCKVQWDWKDP 250
            :|:||..|.|.:|...||.:..|.|: ||:              .:....::.|...|.......
  Fly  1748 MSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQN 1812

  Fly   251 AS---VGGTMCFVVRF---------FQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPN 303
            ||   :|.::..:|:.         .....|.||                         |.:..|
  Fly  1813 ASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYP-------------------------SLSSNN 1852

  Fly   304 NANIAKVKFTVRTAGQYKISV--------LIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVI 360
            :.|||....:..:|||...|.        |...|..:....|..||..
  Fly  1853 SENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLES----------------- 1900

  Fly   361 CCAGAPTLM--------------HIEPRDEF---GNSCL---FDQN----QSDEALQGYQVAI-- 399
             |. ||.|:              ..|..||:   ||:.|   ..:|    ..|||::...|.:
  Fly  1901 -CR-APALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTK 1963

  Fly   400 ---YDLHGVPVEKLQHAIVFAYDKVNSRVSVT-----------ALFPEP-------TCLRAVISY 443
               :|...| :::...|::.|:|....|.:|.           |..|:|       |..:.::..
  Fly  1964 RKSWDDEFV-LKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGL 2027

  Fly   444 R------------DQQLPNGDFDII-----VLSSSDT--------------TLVHKNIA-SRKHN 476
            :            :..|.|.|:.|.     :|..|..              |:|::.:: ..:.:
  Fly  2028 KLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQES 2092

  Fly   477 ICYEAK-------LLSIFG---VSKNKPRKV--------LCYV-----------GPKQNSLIFQV 512
            .|.|::       :.|..|   :|.|.|..:        ||.|           |..|:.:  ..
  Fly  2093 TCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEI--DS 2155

  Fly   513 TIKE---MILK---FIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNI 571
            .:||   .:|.   ||.|:|..             :|..|:..|:.:..:......|..::....
  Fly  2156 DVKEHGVSVLSEDLFISKKITN-------------KLQQQIQDPLVLASNALPNWCENLNQSCPF 2207

  Fly   572 IAATFT---HFLLKNIGGSETF----------------------KDKQDFFYHEVRKFHASYYHE 611
            :....|   :|...:.|.|.:.                      :|..:|....::       ||
  Fly  2208 LFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLK-------HE 2265

  Fly   612 KMALKVQR-EKILESSMKAVKGFSVSDWCGN---FEVTFQGEQGIDWGGLRREWFELV------- 665
            :  :||.| |.:|..:|:.:|     ..|..   .||.|..|:|...|. ..|::.||
  Fly  2266 R--VKVPRNEDLLMWAMQVMK-----THCNRKSVLEVEFLDEEGTGLGP-TLEFYALVAAEIQRS 2322

  Fly   666 --CSALFD-------------ARG-----GLFCTFHDKHQALVHPNPTRPAHLK-----LKHFEF 705
              |..|.|             |.|     |.:.   ::.:..:.|.|. |.:.:     ||:|.|
  Fly  2323 DLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYV---NRREHGIFPAPL-PQNSEICENVLKYFWF 2383

  Fly   706 AGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQ--------------DDPDL 756
            .|..|.|.|.:       .:||....|.|||..|...:|..:..::              :|.|:
  Fly  2384 FGVFVAKVLQD-------MRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDI 2441

  Fly   757 YLSKIKYILDTD---------------LDATDTLELYFVEEMYD----SSSGQLSKTI------- 795
            ..:..| :|.||               |...|.....|::||.:    ..|.:...||
  Fly  2442 VETCTK-LLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHE 2505

  Fly   796 --------------------------------------ELIPNGAKTRVTNATKNQYLDALAQQR 822
                                                  ||:|||:...||......|.:.|....
  Fly  2506 LINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFI 2570

  Fly   823 LCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCG------TGEYSISDFKAHHIANGNSA 881
            |.:.:..::.:|..|.|.:.|...|:.|..:|..:::||      :.|..||..:.....|.:|.
  Fly  2571 LQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSP 2635

  Fly   882 EFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQIT--AAPTFGNLPTAHTC 944
            .|:|    |...:.:.|..|....||||||||.|||||...|:|:..:.  .....|:.|:.:||
  Fly  2636 GFQR----FVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTC 2696

  Fly   945 FNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            .:.|.||||.:.|..::.||.|..|  :||
  Fly  2697 VHYLKLPDYPTEEIMKERLLTATKE--KGF 2724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	20/117 (17%)
		Filamin	238..336	CDD:279024	20/117 (17%)
		HECTc	615..975	CDD:238033	116/482 (24%)
		HECTc	642..974	CDD:214523	106/449 (24%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	117/486 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830