DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and smurf1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001001943.1	Gene:	smurf1 / 321695	ZFINID:	ZDB-GENE-040426-2744	Length:	731	Species:	Danio rerio

Alignment Length:	372	Identity:	122/372 - (32%)
Similarity:	190/372 - (51%)	Gaps:	39/372 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   615 LKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCT 679
            ::|.||:|.|.|.:.:......|......|.|:||:|:|:||:.|||..|:|..:.:...|||..
Zfish   375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQY 439

  Fly   680 FHDKHQAL-VHPNPT-RPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGL 742
            ..|....| ::|:.: .|.|  |.:|.|.|:::|..:|.    |.|   :...|:..|..||:|.
Zfish   440 STDNIYTLQINPDSSINPDH--LSYFHFVGRIMGLAVFH----GHY---INGGFTLPFYKQLLGK 495

  Fly   743 RVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVT 807
            .:.....|..||:|:.|.: :||:.|:  |..|:..|..|  .::.|:..:. ||.|||....||
Zfish   496 PIQLCDLETVDPELHKSLV-WILENDI--TSVLDHTFCVE--HNAFGKFLQH-ELKPNGKNIPVT 554

  Fly   808 NATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKA 872
            ...|.:|:......|....::.:..:..||.|.:||.:||..||..||||::.|.|:..::|:||
Zfish   555 EENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLNDWKA 619

  Fly   873 -----HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAA 932
                 |.:|:.|      ::.|||..|.:|.:....|||||.||.:::|..||:.|..... :|.
Zfish   620 NTRLKHCVADSN------IVKWFWQAVESFDEERRGRLLQFVTGSTRVPLQGFKALQGSTG-SAG 677

  Fly   933 PTF----------GNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISE 969
            |..          .|||.||||||::.:|.|||||:..:.||.|:.|
Zfish   678 PRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	122/372 (33%)
		HECTc	642..974	CDD:214523	115/345 (33%)
smurf1	NP_001001943.1	C2_Smurf-like	14..138	CDD:176028
		WW	234..266	CDD:197736
		WW	280..312	CDD:197736
		HECTc	373..728	CDD:238033	122/372 (33%)
		HECTc	397..728	CDD:214523	116/350 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810