DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4238 and CG42797

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster


Alignment Length:974 Identity:225/974 - (23%)
Similarity:369/974 - (37%) Gaps:238/974 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 GESMGISSLSSCGDPERLPELPPLDEQRLQR--AALHLQQKLILREWLKD---------HRLQHH 124
            |...|.|...:.|:    |.|||..|.|:..  ...::........|.:.         .|.|||
  Fly   622 GTVSGSSGAGAAGE----PPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHH 682

  Fly   125 YQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQNLPT---SKAQLDALKAQLWSTVVKS 186
            .|:|.....:....:  ..:|||:::            .||||   |.|...|..|...:|.:..
  Fly   683 RQQLDRRYQSIRRTI--TNESRAAQL------------YNLPTSANSNANSTAPAAPPPATAIHP 733

  Fly   187 SQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDW-KDP 250
            :            ::.:......:|....:.:||...|::.|:::..:......|..::.: || 
  Fly   734 A------------ILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKD- 785

  Fly   251 ASVGGTMCFVVRFFQRNGQPYPIC-------DTDHFFVEVTEGTRKVVTISELGSSTDPNNANIA 308
                  :..:|..|.:..:..|.|       ....||::  ...|:.       |..||...  .
  Fly   786 ------LVALVNTFAQMSRELPSCWETKLDQSGKQFFID--HQHRRT-------SFMDPRLP--V 833

  Fly   309 KVKFTVR----------TAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCA 363
            :....||          :.|.|...::.|....|.|        |.|:|      .|||:|   :
  Fly   834 ECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATS--------GHINA------SPASSV---S 881

  Fly   364 GAPTLMHIEP-------RDEFGN----------SCLFDQNQS-----DEALQGYQVAIYDLHGVP 406
            |.|.|....|       |...|:          ||..:.::|     ..|..|...|.|:  .||
  Fly   882 GVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYE--DVP 944

  Fly   407 VEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIA 471
            :         ||::     .|.|...:|..|..:   |::|                   .::..
  Fly   945 I---------AYNE-----KVIAFLRQPNILEIL---RERQ-------------------GQHTM 973

  Fly   472 SRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTK 536
            ||:  :..:..:|.:.||      ..|..:|......|.....::.|:.|:|....:.:..|   
  Fly   974 SRQ--LREKINILRVEGV------PALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSP--- 1027

  Fly   537 FHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEV 601
              .|...:.|...|.|..|                                  |:.|...||   
  Fly  1028 --VLNSRMPQRAPPPFRRD----------------------------------FEAKLRSFY--- 1053

  Fly   602 RKFHASYYHE---KMALKVQREKILESSMKAVKGFSVSD-WCGNFEVTFQGEQGIDWGGLRREWF 662
            ||..:..|.:   |:.|.::|..:||.:.:.:...:..| ..|...|.:..|:|:|:||..||:|
  Fly  1054 RKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFF 1118

  Fly   663 ELVCSALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKLKH--FEFAGKMVGKCLFESALGGTYR 724
            .|:...||:...||| .:.:|.:...|.|   ..|.:...|  |.|:|:::|..|       .::
  Fly  1119 FLLSRELFNPYYGLFEYSANDTYTVQVSP---LSAFVDNCHDWFRFSGRVLGLAL-------VHQ 1173

  Fly   725 QLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYF--VEEMYDSS 787
            .|:.|.|:|.|...|:.|.|.....|..|.:.:.| :::|.|.|:.....|.|.|  .||:..|.
  Fly  1174 YLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQS-LQWIRDNDIGTGVDLGLTFCVTEELLGSV 1237

  Fly   788 SGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDE 852
            ..:     ||.|.|....:....|.:||:.:.:.||...|:::.:|.::|...:|...|:|:||.
  Fly  1238 VDR-----ELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDA 1297

  Fly   853 NELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPP 917
            .||||::.||.|...:|::.:........:..:|:.|||..:..||..:..|||||.||.|.:|.
  Fly  1298 RELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPY 1362

  Fly   918 GGFQELN-----PQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGM 976
            .||..|.     .:|.|........||.||||||:|.||.|.:.|...:.||||:.| :..||:
  Fly  1363 EGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE-TNTFGI 1425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720 20/115 (17%)
Filamin 238..336 CDD:279024 20/115 (17%)
HECTc 615..975 CDD:238033 114/370 (31%)
HECTc 642..974 CDD:214523 108/341 (32%)
CG42797NP_572574.2 WW 638..667 CDD:278809 6/28 (21%)
HECTc 1068..1424 CDD:238033 114/372 (31%)
HECTc 1092..1423 CDD:214523 110/347 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446950
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11254
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

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