DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4238 and Hecw2

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_001101688.1 Gene:Hecw2 / 316395 RGDID:1593244 Length:1578 Species:Rattus norvegicus


Alignment Length:1048 Identity:253/1048 - (24%)
Similarity:404/1048 - (38%) Gaps:280/1048 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 SSLSSCGDPERLPELPPLDEQRLQRAALHLQ----------QKLILREWLKDHRLQHHYQRLLAV 131
            |||.|.    |.||.|....|..:..|...:          |:.:...           ..|.||
  Rat   662 SSLESA----RFPETPAFSSQEEEDGACAAEPTSSGPTEGSQESVCTP-----------GSLPAV 711

  Fly   132 EVASLEDVYWLEDSRASKI-------LGKDWQLWSGARQNLPTSKAQLDALKAQLWSTVVKSSQH 189
            :|.|.|:    |.|.|...       ||:.||           .:..|:...|...:....|...
  Rat   712 QVPSREE----EGSGAEATALSEQGELGEVWQ-----------RRGSLEGAAAAATAAATDSQPQ 761

  Fly   190 QD---AWTWGGMLVVSVSVAGLVTLAAMT---QP--SLAPEARHSLLQYVTGKYLLPANCKVQWD 246
            :|   ..|.|.....:....| .|..:.|   ||  || |..|..:.:|......||.|      
  Rat   762 EDGDPGDTQGACEGATAQEEG-ATGGSQTNGHQPLRSL-PSVRQDVSRYQRVDEALPPN------ 818

  Fly   247 WKDPASVGGTMCFV-----VRFFQR-NGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNA 305
            |:......|.:.:|     ...:|| ...|.|         :|.:.:..:..:.:|       |.
  Rat   819 WEARIDSHGRIFYVDHVNRTTTWQRPTAPPAP---------QVLQRSNSIQQMEQL-------NR 867

  Fly   306 NIAKVKFTV-RTAGQYKISVLIGAS-----HIAGSPFLR-SFLPGAIDARRSRFI---RPASTVI 360
            ....::.|: ....:...|.:.||.     |.|.:.|.| :.||.:....|...:   .|...:|
  Rat   868 RYQSIRRTMTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHSTSRSRLTLLLQSPPVKFLI 932

  Fly   361 CCAGAP---TLMHIEP---RDEFGNSCL-------------FDQNQSDEALQGY-------QVAI 399
                :|   |::|..|   |....|:||             |::.|.:..|.|:       |:.:
  Rat   933 ----SPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLEL 993

  Fly   400 YDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTT 464
              ..|..::.......|..|. |||.:               ::.|.:||        |.||..|
  Rat   994 --PRGWEMKHDHQGKAFFVDH-NSRTT---------------TFIDPRLP--------LQSSRPT 1032

  Fly   465 --LVHKNIASRKHNICYEAKLLSIFGVSKN----------KPRKVLCYVGPKQNSLIFQVTIKEM 517
              |||:...:|:.:       .|...|.::          :|......|...|...:..|...:.
  Rat  1033 SALVHRQHLTRQRS-------HSAGEVGEDSRHAGPPVLPRPASTFNTVSRPQYQDMVPVAYNDK 1090

  Fly   518 ILKFIPK----RIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASK----------D 568
            |:.|:.:    .|...|.....:.|.|.:.:.      ||..:|....:.|:|.          :
  Rat  1091 IVAFLRQPNILEILQERQPDLARNHSLREKIQ------FIRTEGTPGLVRLSSDADLVMLLSLFE 1149

  Fly   569 RNIIAATFTHFLL----------------KNIGGSETFKD------KQDF------FYHEVRKFH 605
            ..|::....|.||                :|..|::....      |:||      ||   ||..
  Rat  1150 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFY---RKLE 1211

  Fly   606 ASYYHE---KMALKVQREKILESSMKAVKGFSVSDWCGN-FEVTFQGEQGIDWGGLRREWFELVC 666
            ...|.:   |:.|.::|:.:||.:...:.|:|..|...| ..|||.||:|:|:.|..||:|.||.
  Rat  1212 TKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVS 1276

  Fly   667 SALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKLKH--FEFAGKMVGKCLFESALGGTYRQLVR 728
            ..||:...||| .:.:|.:...:.|   ..|.:...|  |.|:|:::|..|.       ::.|:.
  Rat  1277 RELFNPYYGLFEYSANDTYTVQISP---MSAFVDNHHEWFRFSGRILGLALI-------HQYLLD 1331

  Fly   729 ARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFV--EEMYDSSSGQL 791
            |.|:|.|...|:.:.......|..|.:.:.| ::::.|.|:.  |.|:|.|.  ||::    ||:
  Rat  1332 AFFTRPFYKALLRILCDLSDLEYLDEEFHQS-LQWMKDNDIH--DILDLTFTVNEEVF----GQI 1389

  Fly   792 SKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELE 856
            ::. ||.|.||...||...|.:|::.:.:.|:...|..:.:|.::|...::...|:|:||..|||
  Rat  1390 TER-ELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELE 1453

  Fly   857 LLMCGTGEYSISDFKAHHIANGNSAEFRR-------VLAWFWAGVSNFSQTEMARLLQFTTGCSQ 914
            |::.||.|..::|::       |:.|:|.       |:.||||.|..|:..:..|||||.||.|.
  Rat  1454 LVIAGTAEIDLNDWR-------NNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSS 1511

  Fly   915 LPPGGFQEL----NPQ-------FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAIS 968
            :|..||..|    .|:       .:|||      ||.||||||:|.||.|.|:....:.||.|:.
  Rat  1512 IPYEGFASLRGSNGPRRFCVEKWGKITA------LPRAHTCFNRLDLPPYPSFSMLYEKLLTAVE 1570

  Fly   969 EGSEGFGM 976
            |.|. ||:
  Rat  1571 ETST-FGL 1577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720 18/109 (17%)
Filamin 238..336 CDD:279024 18/109 (17%)
HECTc 615..975 CDD:238033 123/383 (32%)
HECTc 642..974 CDD:214523 115/354 (32%)
Hecw2NP_001101688.1 HECW_N 45..162 CDD:406866
C2_NEDL1-like 185..321 CDD:176073
MDN1 <396..741 CDD:227596 24/108 (22%)
NESP55 <464..632 CDD:115071
WW 815..844 CDD:395320 7/34 (21%)
HECW1_helix 921..987 CDD:408233 14/69 (20%)
WW 993..1024 CDD:197736 7/48 (15%)
HECTc 1222..1576 CDD:238033 123/385 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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