DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Hectd3

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_008762291.1	Gene:	Hectd3 / 313525	RGDID:	1309823	Length:	861	Species:	Rattus norvegicus

Alignment Length:	680	Identity:	137/680 - (20%)
Similarity:	255/680 - (37%)	Gaps:	176/680 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 DEFGNSCLFDQN-----QSDEALQGYQVAIYDLHGVPVEKL-------------QHAIVFAYDKV 421
            :||..|||.|.|     :||.:...:.|.:....|..|:||             :..:|:..:..
  Rat   254 EEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEGD 318

  Fly   422 N----SRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNI---ASRKHNICY 479
            |    |.|::........|   |:......||..:..|:........:..:.:   :||:..:..
  Rat   319 NLKKLSDVNIDETLIGDVC---VLEDMTVHLPVIEIRIVECRDDGIDVRLRGVKIKSSRQRELGL 380

  Fly   480 EAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMIL--KFIPKRIATFRLCPSTKFHFLPQ 542
            .|.|.        :|..::.|  |:......:|..:..:|  :||       ::..|...|.:|.
  Rat   381 NADLF--------QPASLVRY--PRLEGTDPEVLYRRAVLLQRFI-------KILDSVLHHLVPA 428

  Fly   543 LVSQLHGPVFIIDDGAQPKIE------LASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEV 601
            ....|         |...:|:      |.|:.|   .:..|..|..:.....:|..:
  Rat   429 WDHTL---------GTFSEIKQVKQFLLLSRQR---PSLVTQCLRDSESSKPSFMPR-------- 473

  Fly   602 RKFHASYYHEKMALK----VQREKILESSM--KAVKGFSVSDWCGNFEVTFQGEQGID--WGGLR 658
                 .|.:.::|::    ..|:...::::  :..:|...||         :.|:.:|  |....
  Rat   474 -----LYINRRLAMEHRACPSRDPACKNAVFTQVYEGLKPSD---------KYEKPLDYRWPMRY 524

  Fly   659 REWFE--LVCSALFDARGGLFCTFHDKHQALVH------------------------------PN 691
            .:|:|  .:...:.|..||...:..|..:.|..                              ||
  Rat   525 DQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPN 589

  Fly   692 PTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLA---------QLIGLRVHYK 747
            |:.....|   :|:.|:::|     :||.|           :.||.         ||.|..|.:
  Rat   590 PSCRDFAK---YEWIGQLMG-----AALRG-----------KEFLVLALPGFVWKQLSGEEVSW- 634

  Fly   748 YFEQDDP--DLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNAT 810
              .:|.|  |..|.|:..::: .:| .:|.|..|.:|:..::.....:.:||||.|....|....
  Rat   635 --SKDFPAVDSVLVKLLEVME-GVD-KETFEFKFGKELTFTTVLSDQQVVELIPGGTGIVVGYED 695

  Fly   811 KNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDF-KAHH 874
            :.:::..:.:.|| ...|::|.:...||..::|..:|.:....|||..:||..|.::... |...
  Rat   696 RLRFIQLVQKARL-EESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTR 759

  Fly   875 IANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQ---FQITAAPTFG 936
            ..:...::.|  :.:||..::||:..:.:|.|:|.||.|:||...:  :.|.   ::.|.|
  Rat   760 FEDFEPSDTR--VQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIY--IYPDKLGYETTDA---- 816

  Fly   937 NLPTAHTCFNQLCLPDYESYEQFEKSLLLA 966
             ||.:.||.:.|.||.|.|.:..|:.|..|
  Rat   817 -LPESSTCSSTLFLPHYASAKVCEEKLRYA 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	89/407 (22%)
		HECTc	642..974	CDD:214523	85/374 (23%)
Hectd3	XP_008762291.1	APC10-HECTD3	238..371	CDD:176487	23/119 (19%)
Hectd3	XP_008762291.1	HECT	579..845	CDD:395507	74/299 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900