DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Smurf2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001100531.1	Gene:	Smurf2 / 303614	RGDID:	1310067	Length:	748	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	130/370 - (35%)
Similarity:	191/370 - (51%)	Gaps:	38/370 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   615 LKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCT 679
            ::|.||:|.|.|.:.|......|......:.|:||:|:|:||:.|||..|:...:.:...|||..
  Rat   395 IEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQY 459

  Fly   680 FHDKHQAL-VHP-NPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGL 742
            ..|....| ::| :...|.|  |.:|.|.|:::|..:|.    |.|   :...|:..|..||:|.
  Rat   460 SRDDIYTLQINPDSAVNPEH--LSYFHFVGRIMGMAVFH----GHY---IDGGFTLPFYKQLLGK 515

  Fly   743 RVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVT 807
            .:.....|..||||:.|.: :||:.|:  |..|:..|..|  .::.|::.:. ||.|||....||
  Rat   516 SITLDDMELVDPDLHNSLV-WILENDI--TGVLDHTFCVE--HNAYGEIIQH-ELKPNGKSIPVT 574

  Fly   808 NATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKA 872
            ...|.:|:......|....::.:..:..||.|.:||.:||..|||.||||::||.|:..:||:||
  Rat   575 EENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKA 639

  Fly   873 -----HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQEL----NPQF- 927
                 |...:.|      |:.|||..|..|.:...||||||.||.|::|..||:.|    .|:.
  Rat   640 NTRLKHCTPDSN------VVKWFWKAVELFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLF 698

  Fly   928 ---QITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISE 969
               ||.|..  .|||.||||||::.:|.|||||:..:.||.||.|
  Rat   699 TIHQIDACT--NNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEE 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	130/370 (35%)
		HECTc	642..974	CDD:214523	122/343 (36%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028
		PRP40	155..>236	CDD:227435
		WW	159..188	CDD:395320
		WW	252..283	CDD:197736
		WW	298..330	CDD:197736
		HECTc	393..745	CDD:238033	130/370 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910