DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and Wwc1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_002727807.1	Gene:	Wwc1 / 303039	RGDID:	1308329	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	149/745 - (20%)
Similarity:	236/745 - (31%)	Gaps:	229/745 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LIRSFVVYK-GRPPDHATRFDISMLVSHINVGGVMHAATGGKTFPTLKVKLCFGESMGISSLSSC 82
            ||:|..:.| |...|..:..|:....|.:.          ..:||..|..|.......||...|.
  Rat   238 LIKSLAMLKDGFRTDRGSHSDLWSSSSSLE----------SSSFPVPKQFLDVSSQTDISGSFST 292

  Fly    83 GDPERLPELPPL----DEQRLQRAALHLQ-----------------QKLIL----REWLKDHRL- 121
            ....:|.|...|    :|.:.:.|.|.:|                 .:|||    .|.||:.|.
  Rat   293 SSSNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFI 357

  Fly   122 ------QHHYQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQ---NLPTSKAQLDALKA 177
                  |...::|........:|:....|:: ||.|.:..:|.|...|   .|..:..|:.||.:
  Rat   358 SPRKWTQGEVEQLEMARRRLEKDLQAARDTQ-SKALTERLKLNSKRNQLVRELEEATRQVAALHS 421

  Fly   178 QLWSTVVKSSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPS---------------LAPEARHSL 227
            || .::..|.|...:.:..|.|..|.......:|.:.|..|               |..:.....
  Rat   422 QL-KSLSSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSASFTDLYYDPFEQLDSELPSKVELLF 485

  Fly   228 LQYVTGKYLLPANC-------------KVQWDWKDPA--SVGGTMCFVVRFFQRN--GQPYPICD 275
            |:..||  ..|:.|             |.:...:..|  |:.||...:.....|:  ..|.|.|.
  Rat   486 LEGATG--FRPSGCITTIHEDEVAKTQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCS 548

  Fly   276 T---------DHFFVEVT-EGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGASH 330
            .         |.|...:. |.|....|:.||...||.     |:.:|.:...|.
  Rat   549 PLIADPLLAGDAFLTPLEFEDTELSPTLCELSLGTDG-----ARERFRLEEPGP----------- 597

  Fly   331 IAGSPF--LRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNS------------- 380
             .|.|.  ..|..||.           ...|.|.:.|     :......|:|
  Rat   598 -EGKPLGQAASVAPGC-----------GLKVACVSAA-----VSDESVAGDSGVYEASMQRLGTS 645

  Fly   381 --CLFDQNQSDEALQGYQVAI---YD-------LHGVPVEKLQHAIVFAYDKVNSRVSVTALFPE 433
              ..||.::| ||:...||.|   ||       :..:.:..|...::....|||.||::......
  Rat   646 EAAAFDSDES-EAVGVTQVQIALKYDEKSKQFAILVIQLSNLSALLLQQDQKVNIRVAILPCSES 709

  Fly   434 PTCLRAVISYRDQQLPNGDF----DIIVLSSSDTTLVHKNI------ASRKH-NICYEAKLLSIF 487
            .|||     :|.:.|.:.|.    :...:|.|...|..|.:      ..|.| ..|.....:|:.
  Rat   710 STCL-----FRTRPLDSADSLVFNEAFWVSMSYPALHQKTLRVDVCTTDRSHTEECLGGAQISLA 769

  Fly   488 GVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVF 552
            .|.::..|....|     |.|.:         |::.|:...            || .::..||..
  Rat   770 EVCRSGERSTRWY-----NLLSY---------KYLKKQGRE------------PQ-PAEAPGPDH 807

  Fly   553 IIDDGA---QPKIELASKDRNIIAATFTHFLLKNIGGSETFKD-------------------KQD 595
            :....|   |..:||..:.....::       :.:.||.|:::                   ::|
  Rat   808 VDAVSALLEQTAVELEKRQEGRSSS-------QTLEGSWTYEEEASENEAVAEEEEREEEEGEED 865

  Fly   596 FFYHEVRKFHASYYHEKMALKVQREKILES 625
            .|..:|    :....|..||||.||...:|
  Rat   866 VFAEKV----SPEAEECPALKVDRETNTDS 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	24/124 (19%)
		Filamin	238..336	CDD:279024	24/124 (19%)
		HECTc	615..975	CDD:238033	6/11 (55%)
		HECTc	642..974	CDD:214523
Wwc1	XP_002727807.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	378..>420	CDD:299846	11/42 (26%)
		C2_Kibra	661..784	CDD:176062	28/132 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900