DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	133/400 - (33%)
Similarity:	212/400 - (53%)	Gaps:	34/400 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 SETFKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSD------WCGNFEVT 645
            |..||.|.|:|..:::|  .:....:..:|:.|..|.|.|.:.:......|      |     :.
  Rat   878 SREFKQKYDYFRKKLKK--PADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLW-----IE 935

  Fly   646 FQGEQGIDWGGLRREWFELVCSALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKLKHFEFAGKM 709
            |:.|:|:|:||:.||||.|:...:|:...||| .:..|.:...::||........|.:|.|.|::
  Rat   936 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRV 1000

  Fly   710 VGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDT 774
            .|..:|       :.:|:...|.|.|...::|.::.....|..|.: |.:.:|:||:.|   ...
  Rat  1001 AGLAVF-------HGKLLDGFFIRPFYKMMLGKQITLNDMESVDSE-YYNSLKWILEND---PTE 1054

  Fly   775 LELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLN 839
            |:|.|..:  :.:.|| :..::|.|||::..|||..|.:|:|.:.|.|..|.|:.::::||:|..
  Rat  1055 LDLMFCID--EENFGQ-TYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFT 1116

  Fly   840 SIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMAR 904
            .::|.:|:.|||||||||||||.|:..::|::.|.|..........|:.|||..|......:..|
  Rat  1117 ELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 1181

  Fly   905 LLQFTTGCSQLPPGGFQEL----NPQ-FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLL 964
            ||||.||.|::|..||.||    .|| |.|....:...||.||||||:|.||.||::|...:.||
  Rat  1182 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 1246

  Fly   965 LAISEGSEGF 974
            :|: |.::||
  Rat  1247 MAV-ENAQGF 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	125/371 (34%)
		HECTc	642..974	CDD:214523	117/337 (35%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471
		WW	463..489	CDD:395320
		WW	653..682	CDD:395320
		WW	766..796	CDD:238122
		WW	815..865	CDD:197736
		HECTc	926..1255	CDD:214523	119/348 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810