DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and HERC4

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	376	Identity:	92/376 - (24%)
Similarity:	160/376 - (42%)	Gaps:	38/376 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 MALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF 677
            :.|.|:||.|:..:|:.::.....|:....:|.|.||..:|.||:|:|:|.|:...|.|.:.|:|
Human   733 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMF 797

  Fly   678 CTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALG------GTYRQLVRARFSRSFL 736
            ..:.|.............:.|    |...|.:.|..::...:.      ..|::|::.:.|...|
Human   798 RYYEDSRLIWFSDKTFEDSDL----FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDL 858

  Fly   737 AQLIGLRVHYKYFEQDDPDLYLSKIKYILD---TDLDATDTLELYFVEEMYDSSSGQLSKTIELI 798
            .:|:             ||:..| ::.:||   .|::.|..|......|.:.:     ::..||:
Human   859 KELM-------------PDVGRS-MQQLLDYPEDDIEETFCLNFTITVENFGA-----TEVKELV 904

  Fly   799 PNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTG 863
            .|||.|.|....:.:::||........:|....|:|..|.:.:....:|.:|..|||:.::.|..
Human   905 LNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 969

  Fly   864 EYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQ 928
            .|...:.:.:....|........:..||.........:..:.|.|.||..::|..|.:.|....|
Human   970 NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQ 1034

  Fly   929 ITAAPTFGN--LPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            .|..   |.  ||.:|||||.|.||.|...|.....|:.|| :.:|||.::
Human  1035 STGG---GEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAI-DHNEGFSLI 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	91/370 (25%)
		HECTc	642..974	CDD:214523	83/342 (24%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	91/372 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810