DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and MAGI3

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001136254.1	Gene:	MAGI3 / 260425	HGNCID:	29647	Length:	1481	Species:	Homo sapiens

Alignment Length:	663	Identity:	125/663 - (18%)
Similarity:	200/663 - (30%)	Gaps:	278/663 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DISMLVSHINVGGVMHAAT-------------------GGKTFPTLKVKLCFGESMGISSLSSCG 83
            ||...:.|.||..:.|...                   ||...||...|:...:.....||.:..
Human   617 DIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAIN 681

  Fly    84 DPERLPE---LPP----LDEQRLQRAALHLQQKLILREW---LKDHRLQHHYQRLLAVEVASLED 138
            :|  :|:   .||    ....:|..:.::|:.|.:..:.   .||                  .|
Human   682 EP--IPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKD------------------LD 726

  Fly   139 VYW--LEDSRASKIL---GKDWQLWSGARQNLPTSKAQLDA-LKAQ-----LWSTVVKSSQHQDA 192
            |:.  .|.....::|   |.|..::.||  .:|...|:.|. |:|.     :....||...|:
Human   727 VFLRKQESGFGFRVLGGDGPDQSIYIGA--IIPLGAAEKDGRLRAADELMCIDGIPVKGKSHK-- 787

  Fly   193 WTWGGMLVVSVSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTM 257
                       .|..|:|.||.                 .|..||....|:.:..|.|.. ..:.
Human   788 -----------QVLDLMTTAAR-----------------NGHVLLTVRRKIFYGEKQPED-DSSQ 823

  Fly   258 CFVVRFFQRNG----------------QPYPIC----DTDHF-FVEVTEGTR--------KVVTI 293
            .|:   ..:||                :||.:.    :.:.| ||.:|...:        |:..:
Human   824 AFI---STQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRV 885

  Fly   294 SELGSSTD---------------------------------------------------PNNANI 307
            .| ||..|                                                   |:..|.
Human   886 IE-GSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNS 949

  Fly   308 AKVKFTV--RTAGQYKISVLIGASHIAGSPFLRSFLPGAI--DARRS---------RFIRPASTV 359
            |:....:  |..||.:      |:||.|.   ||.|.|.|  |...|         ...:|.:.|
Human   950 ARQSPALQHRPMGQSQ------ANHIPGD---RSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAV 1005

  Fly   360 ICCAGA---------PTLMHIEPRDEFG---------NSCLFDQNQSDE--ALQGYQV----AIY 400
            |...|:         |..:...||. ||         |..||....:::  |::..::    .|.
Human  1006 ISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIV 1069

  Fly   401 DLHGVPVEKLQH--AIVFAYDKVNSRVSV----TALFPEPTCLRAVISYRDQQLPNGDFDIIVLS 459
            :::|.|.:.:.|  ||.......|..:.:    |.|.|:                :||:||...|
Human  1070 EINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPD----------------HGDWDINNPS 1118

  Fly   460 SSDTTLVHKNIASRKHNICYE--------AKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKE 516
            ||              |:.|:        :...|||..|         :|...:.||..|:..|.
Human  1119 SS--------------NVIYDEQSPLPPSSHFASIFEES---------HVPVIEESLRVQICEKA 1160

  Fly   517 MILK-FIPKRIAT 528
            ..|| .:|::.:|
Human  1161 EELKDIVPEKKST 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	27/179 (15%)
		Filamin	238..336	CDD:279024	27/179 (15%)
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..273
		WW	294..326	CDD:197736
		WW	342..372	CDD:238122
		Interaction with PTEN. /evidence=ECO:0000269\|PubMed:10748157	410..492
		PDZ	413..493	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..570
		PDZ	575..656	CDD:214570	6/38 (16%)
		Interaction with ADGRB1. /evidence=ECO:0000269\|PubMed:10748157	726..808		24/113 (21%)
		PDZ_signaling	726..807	CDD:238492	24/112 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..843		3/24 (13%)
		PDZ_signaling	849..935	CDD:238492	11/86 (13%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269\|PubMed:10748157, ECO:0000269\|PubMed:16904289	851..938		9/87 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		12/45 (27%)
		PDZ_signaling	1022..1100	CDD:238492	15/78 (19%)
		Red1	<1132..1461	CDD:311769	13/51 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1481		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900