DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and WWTR1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001161750.1	Gene:	WWTR1 / 25937	HGNCID:	24042	Length:	400	Species:	Homo sapiens

Alignment Length:	107	Identity:	25/107 - (23%)
Similarity:	43/107 - (40%)	Gaps:	24/107 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VSHINVGGVMHAATGGK---------TFPTLKVKLCFGESMGISSLSSCGDPERLP-----ELP- 92
            ::|:|    :|.|....         :.|.|.:.....:.|..|:||....|.:.|     .:|
Human   163 LNHMN----LHPAVSSTPVPQRSMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPN 223

  Fly    93 PLDEQRLQRAALHLQQKLILREWLKDHRLQHHYQRLLAVEVA 134
            .|..|:.|:..|.||:..:.||     |::...:.|:..|.|
Human   224 ALTTQQQQQQKLRLQRIQMERE-----RIRMRQEELMRQEAA 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
WWTR1	NP_001161750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..117
		WW	125..156	CDD:197736
		Required for interaction with PALS1. /evidence=ECO:0000269\|PubMed:21145499	222..400		13/44 (30%)
		PDZ-binding	394..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900