DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and HECTD1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_056197.3	Gene:	HECTD1 / 25831	HGNCID:	20157	Length:	2610	Species:	Homo sapiens

Alignment Length:	1113	Identity:	212/1113 - (19%)
Similarity:	354/1113 - (31%)	Gaps:	394/1113 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LSSCGDPERLPELPPLDEQRLQRAALHLQQKLILREWLKDHRLQHHYQRLLAVEVASLEDVYWLE 143
            |:...|.|.|||....|::...                 |::....|:.::.:...||
Human  1672 LAELDDDEDLPEPDEEDDENED-----------------DNQEDQEYEEVMILRRPSL------- 1712

  Fly   144 DSRASKILGKDWQLWSGARQNLP--TSKAQLDALKAQLWSTVVKSSQHQDAWTWGGM-------L 199
                        |..:|:|.::.  ...:||..:.|...|..:...:.::..|.||.       .
Human  1713 ------------QRRAGSRSDVTHHAVTSQLPQVPAGAGSRPIGEQEEEEYETKGGRRRTWDDDY 1765

  Fly   200 VVSVSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFF 264
            |:....:.||       |:..|....:.:|..|...:.|.
Human  1766 VLKRQFSALV-------PAFDPRPGRTNVQQTTDLEIPPP------------------------- 1798

  Fly   265 QRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGAS 329
               |.|:.....:   ||.|...|..:|:...|..| .....:....|  |:...|.:..|:..|
Human  1799 ---GTPHSELLEE---VECTPSPRLALTLKVTGLGT-TREVELPLTNF--RSTIFYYVQKLLQLS 1854

  Fly   330 HIAGSPFLRSFLPGAIDARRSRFI-RPASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQ 393
                       ..|.:.:.:.|.| .|..|:         |:.|.:|            ||:..:
Human  1855 -----------CNGNVKSDKLRRIWEPTYTI---------MYREMKD------------SDKEKE 1887

  Fly   394 GYQVAIYDLHGVP----VEKLQHAIVFAYDKVNSRVSV----------TALFPEPTCLRAVISYR 444
            ..::..:.:..|.    .::|....:..|.:.|:..:.          .::.....|.:.:.:|:
Human  1888 NGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYK 1952

  Fly   445 D-------QQLPNGDFDIIVLSSSDTTLVHKNIASRK----HNICYEAKLLS----IFGVSKNKP 494
            |       ..|..|  .|..|.|||...:.|.....|    .|.|....:|.    ::.|:.:..
Human  1953 DFCEHGTKSGLNQG--AISTLQSSDILNLTKEQPQAKAGNGQNSCGVEDVLQLLRILYIVASDPY 2015

  Fly   495 RKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQ 559
            .::....|.:|....|...      :|..|:|.|             :::.|:..|: .:..||.
Human  2016 SRISQEDGDEQPQFTFPPD------EFTSKKITT-------------KILQQIEEPL-ALASGAL 2060

  Fly   560 PK--IELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHAS----YYHEKMALKVQ 618
            |.  .:|.||         ..||:       .|:.:|  .|.....|.||    :...:....|:
Human  2061 PDWCEQLTSK---------CPFLI-------PFETRQ--LYFTCTAFGASRAIVWLQNRREATVE 2107

  Fly   619 REKILES-----------------SMKAVKGFSVSDWCGN-----------FEVTFQGEQGIDWG 655
            |.:...|                 .:|..:|.|:.:|..|           .||.|.||:|...|
Human  2108 RTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLG 2172

  Fly   656 GLRREWFELVCSALFDAR--GGLFC--TFHD---KHQAL------------------VHPNPTRP 695
            . ..|::.|| :|.|...  |...|  .|.|   :|..|                  ..|.|...
Human  2173 P-TLEFYALV-AAEFQRTDLGAWLCDDNFPDDESRHVDLGGGLKPPGYYVQRSCGLFTAPFPQDS 2235

  Fly   696 AHLK--LKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSF------------LAQLIGLRVHY 746
            ..|:  .|.|.|.|..:.||:.::       :||....|:.|            :::||
Human  2236 DELERITKLFHFLGIFLAKCIQDN-------RLVDLPISKPFFKLMCMGDIKSNMSKLI------ 2287

  Fly   747 KYFEQDDPDLYL------------------------SKIKYILD----------------TDLDA 771
             |..:.|.||:.                        ||.::|||                .|.:.
Human  2288 -YESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWFNGILTWEDFEL 2351

  Fly   772 TDTLELYFVEEMYD-------------------------------SSSG-QLS------------ 792
            .:.....|::|:.|                               |.|| .||
Human  2352 VNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCP 2416

  Fly   793 -------KTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIF 850
                   ..::|.|:|....:|.....:|:|.:....:...::.::::|..|.|.:.|...||.|
Human  2417 SSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSF 2481

  Fly   851 DENELELLMCGTGEYSISDFKAHHIANGNSAE------------FRRVLAWFWAGVSNFSQTEMA 903
            ...|:::::||....|   :.|..|.|....:            |.|||.       ..|..|..
Human  2482 SHEEVQMILCGNQSPS---WAAEDIINYTEPKLGYTRDSPGFLRFVRVLC-------GMSSDERK 2536

  Fly   904 RLLQFTTGCSQLPPGGFQELNPQFQIT--AAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLA 966
            ..||||||||.|||||...|:|:..:.  ...|..:.|:.:||.:.|.||:|.|.|...:.||.|
Human  2537 AFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERLLAA 2601

  Fly   967 ISEGSEGF 974
            ..|  :||
Human  2602 TME--KGF 2607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	15/97 (15%)
		Filamin	238..336	CDD:279024	15/97 (15%)
		HECTc	615..975	CDD:238033	116/532 (22%)
		HECTc	642..974	CDD:214523	106/475 (22%)
HECTD1	NP_056197.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..269
		Ank_2	366..457	CDD:403870
		ANK repeat	366..393	CDD:293786
		ANK 1	395..424
		ANK repeat	396..426	CDD:293786
		ANK 2	426..455
		ANK repeat	428..457	CDD:293786
		ANK 3	459..491
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..513
		ANK 4	579..612
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	627..657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..748
		Sad1_UNC	1107..1240	CDD:400199
		MIB_HERC2	1277..1335	CDD:399589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1343..1406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1433..1483
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1496..1515
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1592..1611
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1674..1757		19/118 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1777..1797		3/19 (16%)
		BTHB	1892..1965	CDD:408209	8/72 (11%)
		K-box	2029..2103		21/111 (19%)
		HECTc	2131..2608	CDD:238033	113/505 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2297..2318		0/20 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900