DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and pub2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_593926.1	Gene:	pub2 / 2542432	PomBaseID:	SPAC1805.15c	Length:	671	Species:	Schizosaccharomyces pombe

Alignment Length:	781	Identity:	199/781 - (25%)
Similarity:	327/781 - (41%)	Gaps:	209/781 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 KVQWDWKDPASVGGTMCFVVRFF---QRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPN 303
            ::.|.:....:|......:::.|   |:|       :|...||    |....|..|.|..:   |
pombe    51 RLSWGFTQKLTVSPQSIILLQLFDEKQKN-------ETSDGFV----GLGAAVVNSFLPFN---N 101

  Fly   304 NANIAKVKFTVRT-AGQYKISVLIGASHIAGSPFLRS-FLPGAIDARRSRFIRPASTVIC----- 361
            ..:..|.:.|:|: :|.|:.||:        ..|.|| |||..:.|.:|:        ||
pombe   102 PKDDYKTRITLRSPSGSYRGSVV--------CLFKRSKFLPEELPADKSQ--------ICTDIID 150

  Fly   362 ----CAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVN 422
                ||....:      ||||:...         |:..|:::  :..:..|||::.
pombe   151 DASGCAWETRI------DEFGHVYY---------LKSPQLSV--ISAISHEKLENL--------- 189

  Fly   423 SRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIF 487
                      .|..|:.|.|   |.|.|....    ||....|.:|.|   ||       ||..:
pombe   190 ----------TPKQLKEVFS---QFLFNNQSK----SSLKINLEYKVI---KH-------LLEHY 227

  Fly   488 GVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVF 552
            .::.:..::|....||                  :|   |.:.:..|..:|            |:
pombe   228 PLALSVRQQVAVEKGP------------------LP---AGWEMRLSEDYH------------VY 259

  Fly   553 IIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHEKMA--- 614
            .:|...:.......:| |::|   :..:.:|....:...|:..      ||....|...:||
pombe   260 FVDHSTKTTTWSDPRD-NVVA---SDSVSENTDSIQQINDEYQ------RKIAYMYDRPEMAVND 314

  Fly   615 ----LKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGG 675
                |||.|....|.:...:...||||......:.|:.|.|:|:||:.||:|.::..|:|:....
pombe   315 AQLQLKVSRATTFEDAYDIISKLSVSDMKKKLLIRFRNEDGLDYGGVSREFFYILSHAIFNPGYS 379

  Fly   676 LFCTFHDKHQAL-VHP----NPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSF 735
            ||....|.:..| :.|    ||...:     :|.|.|:::|..::       :|:.:..:|...|
pombe   380 LFEYATDDNYGLQISPLSSVNPDFRS-----YFRFVGRVMGLAIY-------HRRYLDVQFVLPF 432

  Fly   736 LAQLIGLRVHYKYFEQ---------DDPDLYLSKIKYILDTDLDATDTLELYF-VEEMYDSSSGQ 790
                      ||...|         |..::|...:|:|.:.|:|  ::|.|.| |||   :..|:
pombe   433 ----------YKRILQKPLCLEDVKDVDEVYYESLKWIKNNDVD--ESLCLNFSVEE---NRFGE 482

  Fly   791 LSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENEL 855
             |.|::|||||....|.|..|..||.||.:.:|..:.:::.::...|||.:|||::|.||:||||
pombe   483 -SVTVDLIPNGRNIAVNNQNKMNYLKALTEHKLVTSTEEQFNALKGGLNELIPDSVLQIFNENEL 546

  Fly   856 ELLMCGTGEYSISDFKAHHIANGNSAEFRR------VLAWFWAGVSNFSQTEMARLLQFTTGCSQ 914
            :.|:.|..:..:.|:|       ...::|.      ::.|||..:|.:|..:.|:||||.||.|:
pombe   547 DTLLNGKRDIDVQDWK-------RFTDYRSYTETDDIVIWFWELLSEWSPEKKAKLLQFATGTSR 604

  Fly   915 LPPGGFQELN-----PQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            ||..||::::     .:|.|........||.||||||:|.:|.|.|.|:.|:.|.:||.| :.||
pombe   605 LPLSGFKDMHGSDGPRKFTIEKVGHISQLPKAHTCFNRLDIPPYNSKEELEQKLTIAIQE-TAGF 668

  Fly   975 G 975
            |
pombe   669 G 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	20/97 (21%)
		Filamin	238..336	CDD:279024	20/97 (21%)
		HECTc	615..975	CDD:238033	121/385 (31%)
		HECTc	642..974	CDD:214523	111/357 (31%)
pub2	NP_593926.1	HUL4	1..671	CDD:227354	199/781 (25%)
		C2_Smurf-like	7..128	CDD:176028	20/98 (20%)
		WW	243..275	CDD:197736	7/64 (11%)
		HECTc	317..669	CDD:238033	121/387 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810