DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and pub1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_594396.1	Gene:	pub1 / 2541818	PomBaseID:	SPAC11G7.02	Length:	767	Species:	Schizosaccharomyces pombe

Alignment Length:	473	Identity:	147/473 - (31%)
Similarity:	232/473 - (49%)	Gaps:	85/473 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 QLVSQLHGP--------------VFIIDDGAQ------PKIELASKDRNIIAATFTHFLLKNIGG 586
            |.|||| ||              |:.:|...:      |::. :|.|:|:.
pombe   339 QPVSQL-GPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLP-SSLDQNVP-------------- 387

  Fly   587 SETFKDKQDFFYHEVRKFHASYYHEKMAL---------KVQREKILESSMKAVKGFSVSDWCGNF 642
                :.|:||    .||.  .|:..:.||         ||:|..|.|.|...:...|.:|.....
pombe   388 ----QYKRDF----RRKL--IYFLSQPALHPLPGQCHIKVRRNHIFEDSYAEIMRQSATDLKKRL 442

  Fly   643 EVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFH----DKHQALVHPNP-TRPAHLKLKH 702
            .:.|.||.|:|:|||.||:|.|:...:|:.   .:|.|.    |.:...::|:. ..|.|  |.:
pombe   443 MIKFDGEDGLDYGGLSREYFFLLSHEMFNP---FYCLFEYSSVDNYTLQINPHSGINPEH--LNY 502

  Fly   703 FEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDT 767
            |:|.|:::|..:|       :|:.|.|.|..||...::..:|..:..|..|.:.|.|.: :|||.
pombe   503 FKFIGRVIGLAIF-------HRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEYYRSLV-WILDN 559

  Fly   768 DLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVD 832
            |:  |..|:|.|..|  |:..|:: .||:|.|||....||...|.:|:|.:...|:...::::.:
pombe   560 DI--TGVLDLTFSVE--DNCFGEV-VTIDLKPNGRNIEVTEENKREYVDLVTVWRIQKRIEEQFN 619

  Fly   833 SFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNF 897
            :|.:|.:.:||..|:::|||.|||||:.|..|..:.|:|.|......| |..:::.|||..:..:
pombe   620 AFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTDYRSYS-ENDQIIKWFWELMDEW 683

  Fly   898 SQTEMARLLQFTTGCSQLPPGGFQELN-----PQFQITAAPTFGNLPTAHTCFNQLCLPDYESYE 957
            |..:.:||||||||.|::|..||::|.     .:|.|..|.....||.||||||:|.||.|.|.:
pombe   684 SNEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRKFTIEKAGEPNKLPKAHTCFNRLDLPPYTSKK 748

  Fly   958 QFEKSLLLAISEGSEGFG 975
            ..:..|.:|:.| :.|||
pombe   749 DLDHKLSIAVEE-TIGFG 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	125/378 (33%)
		HECTc	642..974	CDD:214523	115/341 (34%)
pub1	NP_594396.1	HUL4	1..767	CDD:227354	147/473 (31%)
		C2_Smurf-like	9..131	CDD:176028
		WW	207..236	CDD:278809
		WW	290..319	CDD:278809
		WW	346..378	CDD:197736	4/31 (13%)
		HECTc	413..765	CDD:238033	124/371 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810