DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and pub3

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_595793.1	Gene:	pub3 / 2539956	PomBaseID:	SPBC16E9.11c	Length:	786	Species:	Schizosaccharomyces pombe

Alignment Length:	465	Identity:	142/465 - (30%)
Similarity:	234/465 - (50%)	Gaps:	67/465 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 PQLVSQLHGPVFIIDDGAQPKIELASK----DRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEV 601
            ||.:|.| ||   :..|.:.::..:::    |.|....|:....|.:....:..:.|.||    .
pombe   357 PQSLSHL-GP---LPSGWEMRLTNSARVYFVDHNTKTTTWDDPRLPSALDQDVPQYKCDF----R 413

  Fly   602 RKFHASYYHEKMAL---------KVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGL 657
            ||.  .|:..:..:         ||:|:.|.|.|...:..:|..|......:.|.||.|:|:|||
pombe   414 RKL--IYFRSQPGMRPLPGQCNVKVRRDHIFEDSYAEIMRYSAHDLKKRLMIRFDGEDGLDYGGL 476

  Fly   658 RREWFELVCSALFDARGGLFCTFH----DKHQALVHPNPT-RPAHLKLKHFEFAGKMVGKCLFES 717
            .||:|.|:...:||.   ::|.|.    |.:...::|:.: .|.|  |.:|.|.|:::|..:|
pombe   477 SREFFFLLSHKMFDP---IYCLFEYSAVDNYTLQINPHSSINPEH--LNYFRFIGRVIGLAIF-- 534

  Fly   718 ALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYF-VE 781
                 :|:.:.|.|..|...:|:..:|.....|..|.:.|.| :|::|:.|:  |..|:|.| ||
pombe   535 -----HRRFLDAFFVVSLYKKLLRKKVSLADMESIDAEFYRS-LKWVLENDI--TGILDLTFSVE 591

  Fly   782 EMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNL 846
            |   ...|:: :|:|||.||....||...|.:|:|.:.:.|:...|:.:.::|..|...::..:|
pombe   592 E---DHFGEV-RTVELITNGENIEVTEENKKKYVDLVTEWRVSKRVEQQFNAFYSGFVELVSPDL 652

  Fly   847 LSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFRR------VLAWFWAGVSNFSQTEMARL 905
            :::|||.|||||:.|..:..:.|:|:|       .|:|.      |:.|||..::.:...:.::|
pombe   653 VNVFDERELELLIGGISDVDVEDWKSH-------TEYRTYIATDPVIKWFWEIIAGWKNEDRSKL 710

  Fly   906 LQFTTGCSQLPPGGFQELN-----PQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLL 965
            |||.||.|::|..||::|.     .:|.|..|.|...||.||||||:|.||||.|.:...:.|.|
pombe   711 LQFATGTSRIPVNGFRDLQGSDGPRKFTIEKAGTPDQLPVAHTCFNRLDLPDYPSKDTLHEKLSL 775

  Fly   966 AISEGSEGFG 975
            |: |.:.|||
pombe   776 AV-ENTVGFG 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	123/385 (32%)
		HECTc	642..974	CDD:214523	114/348 (33%)
pub3	NP_595793.1	HUL4	4..786	CDD:227354	142/465 (31%)
		C2_Smurf-like	7..130	CDD:176028
		WW	238..267	CDD:278809
		WW	308..337	CDD:278809
		WW	365..397	CDD:197736	5/34 (15%)
		HECTc	434..784	CDD:238033	123/376 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810