DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and Plekha7

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_017177675.1	Gene:	Plekha7 / 233765	MGIID:	2445094	Length:	1359	Species:	Mus musculus

Alignment Length:	252	Identity:	46/252 - (18%)
Similarity:	83/252 - (32%)	Gaps:	92/252 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VYKGRPPDHATRFD----ISMLVSHINVGG---VMHAATGGKTFPTLKVKLCFGESMGISSLSSC 82
            |.:..|..|.::.:    .|.:||..:..|   .:.|..|.|...:......||:.
Mouse    97 VLREEPHPHMSKPERNQRPSSMVSETSTAGTTSTLEAKPGPKIVKSSSKVHSFGKR--------- 152

  Fly    83 GDPERLPELPPLDEQRLQRAALHLQQKLILREWLKDHRLQHHYQRLLAVEVASLED--VYWLEDS 145
                         :|.::|   :|...:::|.||  |:......||.......|.|  :::.:||
Mouse   153 -------------DQAIRR---NLNVPVVVRGWL--HKQDSSGMRLWKRRWFVLADYCLFYYKDS 199

  Fly   146 RASKILGKDWQLWSGARQNLP-------------------TSKAQLDALKAQLWSTVVKSSQHQD 191
            |...:||           ::|                   :.||....::|.::||....||.:.
Mouse   200 REEAVLG-----------SIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQMEH 253

  Fly   192 AWTWGGMLVVSVSVAGLVTLAA-----------MTQPSL-----------APEARHS 226
            :    ||.....|...|..:.|           :::.||           .|:|.|:
Mouse   254 S----GMRTYYFSADTLEDMNAWVRAMNQAAQVLSRSSLRRDVDKVERQAMPQANHT 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
Plekha7	XP_017177675.1	WW	10..39	CDD:366073
		WW	55..84	CDD:366073
		PH_PEPP1_2_3	158..280	CDD:270068	28/141 (20%)
		Smc	<692..>894	CDD:224117
		PHA03247	<903..1009	CDD:223021
		PRK10263	<912..>1118	CDD:236669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900