DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and NEDD4L

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_006722489.1	Gene:	NEDD4L / 23327	HGNCID:	7728	Length:	1019	Species:	Homo sapiens

Alignment Length:	452	Identity:	144/452 - (31%)
Similarity:	226/452 - (50%)	Gaps:	46/452 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 LHGPVFIIDDGAQ-------PKIELASKDRNIIAATFTHFLLKNIGG-----SETFKDKQDFFYH 599
            |.|..|.||..:|       .:..:.|.|..|............|.|     |..||.|.|:|..
Human   586 LDGRTFYIDHSSQVLCGENDTRESVPSYDSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 650

  Fly   600 EVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSD------WCGNFEVTFQGEQGIDWGGLR 658
            :::|  .:....:..:|:.|..|.|.|.:.:......|      |     :.|:.|:|:|:||:.
Human   651 KLKK--PADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLW-----IEFESEKGLDYGGVA 708

  Fly   659 REWFELVCSALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGT 722
            ||||.|:...:|:...||| .:..|.:...::||........|.:|.|.|::.|..:|
Human   709 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVF------- 766

  Fly   723 YRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSS 787
            :.:|:...|.|.|...::|.::.....|..|.: |.:.:|:||:.|   ...|:|.|..:  :.:
Human   767 HGKLLDGFFIRPFYKMMLGKQITLNDMESVDSE-YYNSLKWILEND---PTELDLMFCID--EEN 825

  Fly   788 SGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDE 852
            .|| :..::|.|||::..|||..|.:|:|.:.|.|..|.|:.::::||:|...::|.:|:.||||
Human   826 FGQ-TYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 889

  Fly   853 NELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPP 917
            |||||||||.|:..::|::.|.|..........|:.|||..|......:..|||||.||.|::|.
Human   890 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPM 954

  Fly   918 GGFQEL----NPQ-FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            .||.||    .|| |.|....:...||.||||||:|.||.||::|...:.||:|: |.::||
Human   955 NGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	126/372 (34%)
		HECTc	642..974	CDD:214523	117/337 (35%)
NEDD4L	XP_006722489.1	C2_NEDD4_NEDD4L	21..179	CDD:175999
		WW	224..250	CDD:278809
		WW	413..442	CDD:278809
		WW	526..556	CDD:238122
		WW	575..625	CDD:197736	9/38 (24%)
		HECTc	662..1016	CDD:238033	126/374 (34%)
		HECTc	686..1015	CDD:214523	119/348 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810