DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and WWC1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_011532787.1	Gene:	WWC1 / 23286	HGNCID:	29435	Length:	1185	Species:	Homo sapiens

Alignment Length:	317	Identity:	65/317 - (20%)
Similarity:	105/317 - (33%)	Gaps:	102/317 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SSLSSCGDPERL-PELPPLDEQ--RLQRAALHLQQKLILREWLKDHRLQHHYQRLLAVE--VASL 136
            ||.||..|||.| .|:.....:  :|:|..:|||.:|..:|        ..:|.|..::  ::..
Human   149 SSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKE--------RGFQTLKKIDKKMSDA 205

  Fly   137 EDVYWLEDSRA----SKILGKDWQLWSGARQNLPTSKAQL-DALKAQLWSTVVKSSQHQDAWTWG 196
            :..|.|::::|    :|.:.|........:|:|..|.|.| |..:....|       |.|.|:..
Human   206 QGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGS-------HSDLWSSS 263

  Fly   197 GMLVVS--------------VSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDW 247
            ..|..|              ..::|...:.:..|  ||.:.| ..|:|...|..|...|
Human   264 SSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQ--LAEKVR-LRLRYEEAKRRLSCQC------ 319

  Fly   248 KDPASVGGTMCFVVRFFQRNGQPYPI-CDTDHFFVEVTEGTRKVV---------------TISEL 296
                                ||..|. .:..|:  ::.:.:.|..               |...|
Human   320 --------------------GQATPSNSELTHY--QLPQASSKTARHLYLDSHFLFSLKRTTLNL 362

  Fly   297 GSSTDPNNANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFI 353
            ||.....||       .:|.....||.:         :.......||.:|:.|.|.|
Human   363 GSVPSCRNA-------CLRWIANLKIQL---------AKLDSEAWPGVLDSERDRLI 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	15/113 (13%)
		Filamin	238..336	CDD:279024	15/113 (13%)
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
WWC1	XP_011532787.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	429..>481	CDD:299846
		C2_Kibra	721..844	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900