DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4238 and HECW1

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:XP_016867371.1 Gene:HECW1 / 23072 HGNCID:22195 Length:1639 Species:Homo sapiens


Alignment Length:896 Identity:210/896 - (23%)
Similarity:356/896 - (39%) Gaps:241/896 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 PSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPICDTDHFFV 281
            |||.||..|    |.|....||.|      |:......|.:.:|                ||...
Human   848 PSLRPEHHH----YPTIDEPLPPN------WEARIDSHGRVFYV----------------DHVNR 886

  Fly   282 EVT----------EGTRKVVTISELGSSTDPNNANIAKVKFTVRT-------AGQYKISVLIGAS 329
            ..|          :|.|:..:|.::    :..|.....::.|:.|       ..|.......|..
Human   887 TTTWQRPTAAATPDGMRRSGSIQQM----EQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGG 947

  Fly   330 HIAGSPFLRSFLPGAIDARRSRFIRPAST--VICCAGAPTLMHIEPRDEF--------------G 378
            ...||.........::|.||...:.|.::  :.....:|.:..|...:.|              .
Human   948 GGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTS 1012

  Fly   379 NSCL-------------FDQNQSDEALQGYQVAIYDL-----HGVPVEKLQHAIVFAYDKVNSRV 425
            ::||             |::.|.:..|..:.....|.     .|..::..|....|..|. |||.
Human  1013 STCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDH-NSRA 1076

  Fly   426 SVTALFPEPTCLRAVISYRDQQLPN----------------GDFDII-------VLSSSDTTLVH 467
            :.   |.:|.     |..::.:|||                |:...:       :|:....:||.
Human  1077 TT---FIDPR-----IPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVA 1133

  Fly   468 KNIASRKHN---ICYEAKLL------SIFGVSKNKP---------RKVLCYVGPKQN-------- 506
            ...:..:|.   :.|..|::      :||.:.:.:.         |:.:.|:..:.|        
Human  1134 AIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSC 1198

  Fly   507 --SLIFQVTI-KEMILKFIPKRIATFRLCPSTKFH----FLPQLVSQLHGPVFIIDDGAQPKIEL 564
              .|:..::: :|.|:.::|.:.|         ||    |.|: .|....|      ...|.::.
Human  1199 DADLVILLSLFEEEIMSYVPLQAA---------FHPGYSFSPR-CSPCSSP------QNSPGLQR 1247

  Fly   565 AS--------KDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHE---KMALKVQ 618
            ||        :|                     |:.|...||   ||..|..:.:   |:.|.::
Human  1248 ASARAPSPYRRD---------------------FEAKLRNFY---RKLEAKGFGQGPGKIKLIIR 1288

  Fly   619 REKILESSMKAVKGFSVSDWCGN-FEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF-CTFH 681
            |:.:||.:...|..:|..:...| ..|||.||:|:|:.|..||:|.|:...||:...||| .:.:
Human  1289 RDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN 1353

  Fly   682 DKHQALVHPNPTRPAHLK--LKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRV 744
            |.:...:.|   ..|.::  |:.|.|:|:::|..|.       ::.|:.|.|:|.|...|:.|..
Human  1354 DTYTVQISP---MSAFVENHLEWFRFSGRILGLALI-------HQYLLDAFFTRPFYKALLRLPC 1408

  Fly   745 HYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFV--EEMYDSSSGQLSKTIELIPNGAKTRVT 807
            .....|..|.:.:.| ::::.|.::  ||.|:|.|.  ||::    ||:::. ||...||.|:||
Human  1409 DLSDLEYLDEEFHQS-LQWMKDNNI--TDILDLTFTVNEEVF----GQVTER-ELKSGGANTQVT 1465

  Fly   808 NATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKA 872
            ...|.:|::.:.:.|:...|..:.::.::|...::...|:|:||..||||::.||.|..::|:: 
Human  1466 EKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWR- 1529

  Fly   873 HHIANGNSAEFR-------RVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELN-----P 925
                  |:.|:|       .|:.||||.|..|:..:..|||||.||.|.:|..||..|.     .
Human  1530 ------NNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLR 1588

  Fly   926 QFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGM 976
            :|.|.......:||.||||||:|.||.|.||....:.||.|:.|.|. ||:
Human  1589 RFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETST-FGL 1638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720 18/114 (16%)
Filamin 238..336 CDD:279024 18/114 (16%)
HECTc 615..975 CDD:238033 120/377 (32%)
HECTc 642..974 CDD:214523 113/348 (32%)
HECW1XP_016867371.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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