DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Ube3a

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001380595.1	Gene:	Ube3a / 22215	MGIID:	105098	Length:	870	Species:	Mus musculus

Alignment Length:	754	Identity:	173/754 - (22%)
Similarity:	317/754 - (42%)	Gaps:	160/754 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 SELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGA------SHIAGSPFLRSFLPGAIDARRSRF 352
            |.:|.|:..:| |:.|:       |...::|.|.|      |.:|......:||...:      :
Mouse   207 SRMGDSSQGDN-NVQKL-------GPDDVTVDIDAIRRVYSSLLANEKLETAFLNALV------Y 257

  Fly   353 IRPASTVICCAGAPTLMHIEPRDE---------FGNSCLFDQNQSDEALQGYQVAIYDLHGVPVE 408
            :.|  .|.|..   |..::..||.         ..||.|......:.||..:..|:..|   |:|
Mouse   258 LSP--NVECDL---TYHNVYTRDPNYLNLFIIVMENSNLHSPEYLEMALPLFCKAMCKL---PLE 314

  Fly   409 KLQHAIVFAYDKVNS----RVSVTALFPEPTCLRAVISYR-------DQQLPNGDFDIIVLSSSD 462
             .|..::..:.|.::    |:..|        .:.:|:|:       .:.|.|.|..|:..|...
Mouse   315 -AQGKLIRLWSKYSADQIRRMMET--------FQQLITYKVISNEFNSRNLVNDDDAIVAASKCL 370

  Fly   463 TTLVHKNI----ASRKHN---------ICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTI 514
            ..:.:.|:    ....||         ...|..|..:.|..:...:      ||:.:.|..::.:
Mouse   371 KMVYYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGDERRNKK------GPRVDPLETELGV 429

  Fly   515 KEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIID-DGAQPKIELASKDRNIIAATFTH 578
            |.:..:   |.:.:|.           :.:::....|..:| |....|:|..:|...:......:
Mouse   430 KTLDCR---KPLISFE-----------EFINEPLNDVLEMDKDYTFFKVETENKFSFMTCPFILN 480

  Fly   579 FLLKNIGGSETFKDKQDFFYHEVRKFHASY-------YHEKMALKVQREKILESSMKAVKGFSV- 635
            .:.||:|   .:.|.:...|.| |:....|       .:..:.|||:|:.|::.::..::..::
Mouse   481 AVTKNLG---LYYDNRIRMYSE-RRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAME 541

  Fly   636 --SDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHL 698
              :|......|.|:||||:|.||:.:|:|:||...:|:...|:|.  :|:...|...||:
Mouse   542 NPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFT--YDEATKLFWFNPS----- 599

  Fly   699 KLKHFEFAGK------MVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLY 757
               .||..|:      ::|..::.:.:...:..:|..|       :|:|.:..::......|.||
Mouse   600 ---SFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR-------KLMGKKGTFRDLGDSHPVLY 654

  Fly   758 LSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKT--------IELIPNGAKTRVTNATKNQY 814
            .| :|.:|:.:....|.:.:.|          |:|:|        .:|..||.|..:||..:.::
Mouse   655 QS-LKDLLEYEGSVEDDMMITF----------QISQTDLFGNPMMYDLKENGDKIPITNENRKEF 708

  Fly   815 LDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLS-IFDENELELLMCGTGEYSISDFKAHHIANG 878
            ::..:...|..:|:.:..:|.:|.:.:..::.|. :|...|:|||:||:...   ||:|......
Mouse   709 VNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNL---DFQALEETTE 770

  Fly   879 NSAEFRR---VLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITA--APTFGNL 938
            ....:.|   |:..||..|.:|:..:....||||||..:.|.||..:|.   .|.|  .|....|
Mouse   771 YDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDTERL 832

  Fly   939 PTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            ||:|||||.|.||:|.|.|:.::.||.||:. ::||||:
Mouse   833 PTSHTCFNVLLLPEYSSKEKLKERLLKAITY-AKGFGML 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	12/47 (26%)
		Filamin	238..336	CDD:279024	12/47 (26%)
		HECTc	615..975	CDD:238033	104/382 (27%)
		HECTc	642..974	CDD:214523	97/351 (28%)
Ube3a	NP_001380595.1	AZUL	27..81	CDD:406862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..223		6/23 (26%)
		HECTc	518..868	CDD:238033	104/384 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810