DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and Hace1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_006512697.1	Gene:	Hace1 / 209462	MGIID:	2446110	Length:	921	Species:	Mus musculus

Alignment Length:	809	Identity:	201/809 - (24%)
Similarity:	334/809 - (41%)	Gaps:	170/809 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 CKVQWDW------KDPASVGGTMCFVVR----FFQRNG-QPYPICDTDHF----FVEVTEGTRKV 290
            |.:.|.|      :|.|.:     .::|    ...:|| .|..:|....:    .|.:....|..
Mouse   209 CLIFWTWIHSHGQRDTAQI-----LLLRGAKYLPDKNGVTPLDLCVQGGYGQTCEVLIQYHPRLF 268

  Fly   291 VTISELGSSTDPNNANIAKV--KFTVRTAGQYKISVLIGASHIA---GSPFLRSFLPGAIDARRS 350
            .||.::..:.|.....:.:|  ..:.::..|| :.:|.|.:.:|   |...|.  |....||:..
Mouse   269 QTIVQMTQNEDLRENMLRQVLQHLSQQSESQY-LKILTGLAEVATTNGHKLLS--LSSNYDAQMK 330

  Fly   351 RFIRPASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHA-- 413
            ..:| ...:.|     .:..|.|..        ..|..|....|.:.....:. .|:|.|.|:
Mouse   331 SLLR-IVRIFC-----HVFRIGPSS--------PSNGIDMGYNGNKTPRSQVF-KPLELLWHSLD 380

  Fly   414 ---IVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPN---------GDFDIIVLSSSDT--- 463
               ::.|.:.:.::...|.:    |.:......:||:.|:         |.::.:.....|:
Mouse   381 EWLVLIATELMKNKEDSTDI----TSILLKQKGQDQEAPSLSAFEPPGPGSYESLPPGPGDSKPE 441

  Fly   464 TLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVL--------CYVGPKQNS---LIFQVTIKEM 517
            .|..:..||        |....:..|:.|:...|:        |.:.|...|   :.|.....|:
Mouse   442 VLAGEQEAS--------ADCQDVISVTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEV 498

  Fly   518 ILKFI---PKRIATFRLCPSTKFHFL---PQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATF 576
            :..|:   ||.|       ...||||   |:|:|:                             |
Mouse   499 LKCFVNRNPKII-------FDHFHFLLECPELMSR-----------------------------F 527

  Fly   577 THFLLKNIGGSETFKDKQDFFYHEVRKFH--ASYYH----EKMALKVQREKILESSMKAVKGFSV 635
            .|.:     .::.|||:.::||..:....  :...|    |...|.|.|:.|..||.:.|...:.
Mouse   528 MHII-----KAQPFKDRCEWFYEHLHSGQPDSDMVHRPVSENDILLVHRDSIFRSSCEIVSKANC 587

  Fly   636 SDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF------CTFHDKHQALVHPNPTR 694
            :.......|.|.||:|:. .|:.||||:::.:.:.:....||      .||.....:.|:|:
Mouse   588 AKLKQGIAVRFHGEEGMG-QGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPD--- 648

  Fly   695 PAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLS 759
                .|.:|.|||:::|..|       .:||||...|:|||...::|:.|:|:.....||: |..
Mouse   649 ----HLNYFRFAGQILGLAL-------NHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPE-YAK 701

  Fly   760 KIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLC 824
            .:::|||.|:.... |||.|..|  ....|.:.: :.|.|.|....||...|.:|:..:.:.|:.
Mouse   702 NLQWILDNDISDLG-LELTFSVE--TDVFGAMEE-VPLKPGGGSILVTQNNKAEYVQLVTELRMT 762

  Fly   825 NNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDF-KAHHIANGNSAEFRRVLA 888
            ..::.::::||:|.:..||.:|:.:|||.|||||:.|..|..::|: |.....:|...| ..|:.
Mouse   763 RAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYERE-DPVIQ 826

  Fly   889 WFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELN-----PQFQITAAPTFGN-LPTAHTCFNQ 947
            |||..|.:.:|.|...||||.||.|::|.|||..:.     ..|.|.|.|...| |||:.||.|.
Mouse   827 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINM 891

  Fly   948 LCLPDYESYEQFEKSLLLAISEGSEGFGM 976
            |.||:|.|.|..:..||:|:..||.|:.|
Mouse   892 LKLPEYPSKEILKDRLLVALHCGSYGYTM 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	22/114 (19%)
		Filamin	238..336	CDD:279024	22/114 (19%)
		HECTc	615..975	CDD:238033	123/372 (33%)
		HECTc	642..974	CDD:214523	115/344 (33%)
Hace1	XP_006512697.1	ANK repeat	66..95	CDD:293786
		Ank_2	69..194	CDD:372319
		ANK repeat	97..128	CDD:293786
		ANK repeat	130..161	CDD:293786
		ANK repeat	163..194	CDD:293786
		Ank_2	168..263	CDD:372319	11/58 (19%)
		ANK repeat	196..233	CDD:293786	6/28 (21%)
		HECTc	566..915	CDD:238033	120/369 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810