DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4238 and hecd-1

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_001368365.1 Gene:hecd-1 / 177486 WormBaseID:WBGene00016405 Length:2650 Species:Caenorhabditis elegans


Alignment Length:842 Identity:174/842 - (20%)
Similarity:303/842 - (35%) Gaps:261/842 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 WKDPASVGGTMCFVVRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNANIAK-- 309
            |:|.|:|..|...::..|    .|.|.....:..:||...|    .:.:.| ||..:::.|.|  
 Worm  1953 WEDDATVKCTFEALIPAF----DPRPGRSNVNQTLEVELPT----VVKDFG-STKASSSKIDKDD 2008

  Fly   310 -VKFTVRTAGQYKI-SVLIGASHIAGSPF-----LRSFLPGAIDARRSRFI-RPASTVICCAGAP 366
             ::|.:|......: :|.|..:..:.|.|     :.:.:..|..:.|||.| .|..::..|:...
 Worm  2009 QMRFFLRGPNMSGVDNVTIEMNDDSASLFRYMQIINNSVNWATKSDRSRRIWEPTYSICYCSADQ 2073

  Fly   367 TLMHIE--PRDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAI--------VFAYDKV 421
            |.:.:.  |.:|....|  ..||..|.:           |: :.::|.|:        ||..||:
 Worm  2074 TNVEVSKIPDEESSTPC--QVNQCLETI-----------GL-LSRIQQAMPEAEITPNVFISDKL 2124

  Fly   422 NSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSD-----TTLVHK-----NIASRKHN 476
            ..:|:            .|:|           |.:|:::..     :.||:|     .:.:|  |
 Worm  2125 TLKVT------------QVLS-----------DALVVAARSLPEWCSRLVYKYPCLFTVETR--N 2164

  Fly   477 ICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLP 541
            :..:|   :.||||:.                          :.::.:|                
 Worm  2165 MYMQA---TAFGVSRT--------------------------IVWLQQR---------------- 2184

  Fly   542 QLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHA 606
                         .|.|..:...:::..|..||                  :|...|||.|.  .
 Worm  2185 -------------RDAAVERARGSAQAGNSSAA------------------RQHDRYHEYRV--G 2216

  Fly   607 SYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFD 671
            ...||::.:....|.:|:.:::.:|..  :|.....|:.:..|:|...|. ..|::.||.:.|..
 Worm  2217 RLRHERVKVTRAEETLLDQAIRLMKFH--ADRKAVLEIEYTNEEGTGLGP-TLEFYALVAAELQR 2278

  Fly   672 ARGGLF-CTFHDKHQAL-------------------------VHPNPTRPAHLKLKH----FEFA 706
            ....|: |...|.|.:.                         :.|.|..|...:.|.    |...
 Worm  2279 KSLALWVCDDDDTHASKSGEEREVDLGEGKKPIGYYVRRVGGLFPAPLPPGTDETKRAADMFRVL 2343

  Fly   707 GKMVGKCLFESALGGTYRQLVRARFSRSFLAQLI---------GLRVH----YKYFEQDDP--DL 756
            |..:.|.|.:.       :||....||.||..|:         |..:|    ...||:.:|  ..
 Worm  2344 GVFLAKVLLDG-------RLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILSLDDFEEVNPVKGS 2401

  Fly   757 YLSKIKYIL--------DTDLDATD------TLELYF------VEEM-YDSSSGQLSKT-----I 795
            :|.:::.:.        ||.:|:..      .|:|:.      ||:: .:.:....||.     :
 Worm  2402 FLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFTVNPPSKVFQYAEM 2466

  Fly   796 ELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMC 860
            ||:..|:...||.....||::...:..|...:..::.:|..|.:.:.|...|..:...|::.|:.
 Worm  2467 ELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQRLLS 2531

  Fly   861 G--TGEYSISDFKAHHIAN------GNSAE---FRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQ 914
            |  ..|:|..|     |.|      |.:.|   |.|    |...:...:..|....|||.||||.
 Worm  2532 GEQCPEWSRDD-----ILNYTEPKLGYTRESPGFLR----FVDVMEALTAQERKNFLQFATGCSS 2587

  Fly   915 LPPGGFQELNPQFQIT--AAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            |||||...|:|:..|.  .....|:.|:.:||.:.|.||:|.|.....:.||.||:|  :||
 Worm  2588 LPPGGLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLTAINE--KGF 2647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720 21/92 (23%)
Filamin 238..336 CDD:279024 21/92 (23%)
HECTc 615..975 CDD:238033 103/444 (23%)
HECTc 642..974 CDD:214523 97/415 (23%)
hecd-1NP_001368365.1 Ank_2 345..436 CDD:403870
ANK repeat 345..372 CDD:293786
ANK repeat 374..403 CDD:293786
PTZ00322 383..>497 CDD:140343
ANK repeat 405..436 CDD:293786
F5_F8_type_C 1243..1365 CDD:419973
MIB_HERC2 1452..1509 CDD:399589
HECTc 2221..2648 CDD:238033 104/448 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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