DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and eel-1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001294472.1	Gene:	eel-1 / 177084	WormBaseID:	WBGene00022069	Length:	4185	Species:	Caenorhabditis elegans

Alignment Length:	457	Identity:	146/457 - (31%)
Similarity:	227/457 - (49%)	Gaps:	60/457 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 IDDGAQPKIELASKDRNII----------------AATFTHF--LLKNIGGSETFKDKQDFFYHE 600
            :|......||.|.|.|.::                .|..|.|  ||       .|..|:.:|..|
Worm  3752 LDPDTAKLIEFAEKHRQVLNQALRQNNAVLSAGGPFAILTQFPKLL-------DFDVKRKYFRKE 3809

  Fly   601 VRKFHAS------YYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRR 659
            :.|...|      |....::::|.|.::...|.:.:.....|:|...|.:.||||:|.|.|||.|
Worm  3810 LTKLEPSNSRMPRYRRNDVSVQVSRNRVFSDSFRELFRLRPSEWKNRFYIIFQGEEGQDAGGLLR 3874

  Fly   660 EWFELVCSALFDARGGLFCTF-HDKHQALVH-PNPTRPAHLKLKHFEFAGKMVGKCLFESALGGT 722
            |||.::...:|:....||.|. .|....::: .:...|.|  |.:|:|.|:::.|.:||......
Worm  3875 EWFSVITREIFNPNYALFITAPGDMVTYMINKASYINPEH--LDYFKFVGRLIAKSVFEHKYLDC 3937

  Fly   723 YRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSS 787
            |       |:|:|...::.|.|.|:..|.:||..:.| :.::|...:|.. .|:|.|..|:.:..
Worm  3938 Y-------FTRAFYKHILNLPVRYQDLESEDPAFFKS-LDFLLQNPIDDL-ALDLTFSTEVEEFG 3993

  Fly   788 SGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDE 852
               :....:|.|||.|..|.:|.|::|:..:.|.::..:::.::|:||.|...|||.:|:|:|:|
Worm  3994 ---VRSVRDLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNE 4055

  Fly   853 NELELLMCGTGEYSISDFKAHHIANGNSAEFRRV---LAWFWAGVSNFSQTEMARLLQFTTGCSQ 914
            .|||||:.|.....|.|.    .||.:...|::.   :.|||..:.:|.:.:.|:.|||.||.|:
Worm  4056 QELELLISGLPTVDIDDM----AANTDYKGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSK 4116

  Fly   915 LPPGGFQELN-----PQFQITAAPTFGN-LPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEG 973
            :|..||..|.     .:|.|......|: ||.||||||||.||.|||||:..:||||||.|.:||
Worm  4117 VPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIRECTEG 4181

  Fly   974 FG 975
            ||
Worm  4182 FG 4183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	126/370 (34%)
		HECTc	642..974	CDD:214523	120/342 (35%)
eel-1	NP_001294472.1	DUF908	95..376	CDD:283630
		DUF913	573..936	CDD:283642
		UBA_VP13D	1442..1476	CDD:270491
		WWE	1787..1846	CDD:295449
		DUF4414	2983..3120	CDD:291075
		HECTc	3830..4183	CDD:238033	126/370 (34%)
		HECTc	3854..4182	CDD:214523	120/345 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920