DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and Itch

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001230641.1	Gene:	Itch / 16396	MGIID:	1202301	Length:	864	Species:	Mus musculus

Alignment Length:	959	Identity:	234/959 - (24%)
Similarity:	351/959 - (36%)	Gaps:	251/959 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 SKAQLDA-----LKAQLWSTVVKSSQHQDAWTW-GGMLVVSVSVAGLVTLAAMTQPSLAPEARHS 226
            |..|||:     :|:||..||:.:...::...| |....|.|:|.|..........:.:|:
Mouse     4 SGPQLDSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPK---- 64

  Fly   227 LLQYVTGKYLLPANCKVQWDWKDPASVGGT----MCF---------------------------- 259
                                ||.|.:|..|    :||
Mouse    65 --------------------WKQPLTVIVTPTSKLCFRVWSHQTLKSDVLLGTAGLDIYETLKSN 109

  Fly   260 ------VVRFFQRNGQPYP--------ICDTDHFFVE---VTEG----------------TRKVV 291
                  ||...|..|...|        :| .|...||   ||.|                ||...
Mouse   110 NMKLEEVVMTLQLVGDKEPTETMGDLSVC-LDGLQVEAEVVTNGETSCSESTTQNDDGCRTRDDT 173

  Fly   292 TISELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPA 356
            .:|..||. ||..|...:.|   |..|....|:..|....:..|  |...|.....|     |||
Mouse   174 RVSTNGSE-DPEVAASGENK---RANGNNSPSLSNGGFKPSRPP--RPSRPPPPTPR-----RPA 227

  Fly   357 STVICCAGAPTLMHIEPRDEFGNS--------CLFDQNQSDEALQGYQVAIYDLHGVPVEKL--- 410
            |.    .|:|:    ...|..|:|        ...:.:.|:.|..|..:.:....|.....|
Mouse   228 SV----NGSPS----TNSDSDGSSTGSLPPTNTNVNTSTSEGATSGLIIPLTISGGSGPRPLNTV 284

  Fly   411 --------------QHAIVFAYDKVNSRV----------------------------SVTALFPE 433
                          ||..|:..|.|..|.                            :.|..:..
Mouse   285 SQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQR 349

  Fly   434 PTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVL 498
            || |.:|.:|...||...... ..:...:...::.|              ..:|..|:||....|
Mouse   350 PT-LESVRNYEQWQLQRSQLQ-GAMQQFNQRFIYGN--------------QDLFATSQNKEFDPL 398

  Fly   499 CYVGP---------KQNSLIFQVTIKEMILKFIPKR----IATFRLCPSTKFHF----LPQLVSQ 546
               ||         ..|..::.|.....|.::...|    :....|....:..|    :|..|..
Mouse   399 ---GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDH 460

  Fly   547 LHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHE 611
            .......||    |:...::.|..           ..|.....||.|..:|....::. |...|.
Mouse   461 NRRATTYID----PRTGKSALDNG-----------PQIAYVRDFKAKVQYFRFWCQQL-AMPQHI 509

  Fly   612 KMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGL 676
            |  :.|.|:.:.|.|.:.:..||..|......|.|.||:|:|:||:.||||.|:...:.:.   :
Mouse   510 K--ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNP---M 569

  Fly   677 FCTFH--DKHQALVHPNPT---RPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFL 736
            :|.|.  .|....:..||.   .|.|  ||:|.|.|:.:...||       :.:.:...||..|.
Mouse   570 YCLFEYAGKDNYCLQINPASYINPDH--LKYFRFIGRFIAMALF-------HGKFIDTGFSLPFY 625

  Fly   737 AQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNG 801
            .:::...|..|..|..||:.|.|.| ::.:.:::... ||:||  .:.....|:: |:.:|.|||
Mouse   626 KRILNKPVGLKDLESIDPEFYNSLI-WVKENNIEECG-LEMYF--SVDKEILGEI-KSHDLKPNG 685

  Fly   802 AKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYS 866
            ....||...|.:|:..:|:.||...|:::..:|.:|.|.|:|...|..||..|||:|:||..|..
Mouse   686 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEID 750

  Fly   867 ISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQEL----NPQ- 926
            ::|::.|.|....:...:::: |||..|......:..|||||.||..:||.|||.:|    .||
Mouse   751 LNDWQRHAIYRHYTRTSKQIM-WFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQK 814

  Fly   927 FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFG 975
            |.|........||.:|||||:|.||.|:||||.::.||.||.| :||||
Mouse   815 FCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	32/162 (20%)
		Filamin	238..336	CDD:279024	32/162 (20%)
		HECTc	615..975	CDD:238033	124/369 (34%)
		HECTc	642..974	CDD:214523	116/341 (34%)
Itch	NP_001230641.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	25/147 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..294		32/161 (20%)
		WW	289..318	CDD:278809	6/28 (21%)
		WW	321..350	CDD:278809	1/28 (4%)
		Required for interaction with FYN. /evidence=ECO:0000250	356..432		14/93 (15%)
		WW	401..430	CDD:278809	3/28 (11%)
		WW	440..471	CDD:197736	6/34 (18%)
		HECTc	509..862	CDD:238033	125/373 (34%)
		HECTc	533..861	CDD:214523	117/346 (34%)
		MAP kinase docking site	535..544		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810