DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	229	Identity:	45/229 - (19%)
Similarity:	77/229 - (33%)	Gaps:	88/229 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   552 FIIDDGAQPKIELASKDRN-----IIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHE 611
            ||:.:  :|...::.:|||     :::.|.|      .|.:.|.:.|..
Human    97 FILQE--EPNPHMSKQDRNQRPSSMVSETST------AGTASTLEAKPG---------------- 137

  Fly   612 KMALKVQREKILESSMKAVKGFSVSDWC----GNFEVTFQG---EQGIDWGGLR---REWFELVC 666
                    .||::||.| |..|...|..    .|..|..:|   :|  |..|:|   |.||.|..
Human   138 --------PKIIKSSSK-VHSFGKRDQAIRRNPNVPVVVRGWLHKQ--DSSGMRLWKRRWFVLAD 191

  Fly   667 SALFDARGGLFCTFH---DKHQALVHP--------NPTRPAHLKLKHFEFAGKMVG--KCLFESA 718
                      :|.|:   .:.:|::..        :|..|.....:.:.|.....|  ..::.|:
Human   192 ----------YCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSS 246

  Fly   719 LGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQD 752
            ..|:.             |:..|:|.:  ||..|
Human   247 TAGSQ-------------AEQSGMRTY--YFSAD 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	34/161 (21%)
		HECTc	642..974	CDD:214523	25/130 (19%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068	26/134 (19%)
		NESP55	<299..460	CDD:115071
		DUF1640	779..905	CDD:311647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900