DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and HECTD2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	545	Identity:	137/545 - (25%)
Similarity:	216/545 - (39%)	Gaps:	111/545 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   504 KQNSLIFQVTIKEMI---LKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELA 565
            ||.|.:.|...|:::   |:||     :.||.|:....|.|........|      .|...:.|.
Human   274 KQYSRLSQKRFKQLVERLLQFI-----SLRLFPAKPEEFPPITKCSWWIP------SAAKVLALL 327

  Fly   566 SKDRNII-----------AATFTHFLL-------KNIGGSETFKDKQDFFYHEV--RKFHASYYH 610
            :...|::           .:|..|..|       :|.|.|..|...|..|...|  :|.......
Human   328 NTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDS 392

  Fly   611 EKMALKVQREKILES--------------SMKAVKGFSVSDWCG-----------NFEVTFQGEQ 650
            |:..:.:.|:.:::.              :||..:...|||...           ..:|||.||.
Human   393 EQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEA 457

  Fly   651 GIDWGGLRREWFELVCSALFDARGGLFCTFH-DKHQALVHPNPTRPAHL-------KLKHFEFAG 707
            |:|.|||.:|||.|:...:|....|:| |:| |.|           .|.       ....|...|
Human   458 GLDMGGLTKEWFLLLIRQIFHPDYGMF-TYHKDSH-----------CHWFSSFKCDNYSEFRLVG 510

  Fly   708 KMVGKCLFESALGGTYRQLVRARFSRSFLAQLI---------GLRVHYKYFEQDDPDLYLSKIKY 763
            .::|..::.|.       .:..||......:|:         .:.|.......||....:.::.:
Human   511 ILMGLAVYNSI-------TLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAH 568

  Fly   764 ILDTDLDATDTLE--LYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNN 826
            .|...|.....:|  .|...:::....| :.|:..|.|.|.|..|||..:.:|:.......|..:
Human   569 GLSELLSHEGNVEEDFYSTFQVFQEEFG-IIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKS 632

  Fly   827 VKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNS----AEFRRVL 887
            :..:..:|..|.:|:...|.|.:....|:|:|:||:     .|...|.:.....    |:....:
Human   633 IYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGS-----PDLDMHALQRSTQYDGYAKTDLTI 692

  Fly   888 AWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAPTFGN-LPTAHTCFNQLCLP 951
            .:||..|..|......:||.||||..::|.||..:||  |:|:...|..| ||.|||||||||||
Human   693 KYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLN--FKISKNETSTNCLPVAHTCFNQLCLP 755

  Fly   952 DYESYEQFEKSLLLAISEGSEGFGM 976
            .|:|.:..::.|::.|| .|||||:
Human   756 PYKSKKDLKQKLIIGIS-NSEGFGL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	106/408 (26%)
		HECTc	642..974	CDD:214523	99/355 (28%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033	105/384 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810