DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and Ube3b

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	536	Identity:	142/536 - (26%)
Similarity:	215/536 - (40%)	Gaps:	104/536 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 VTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDD----------------GAQP 560
            |||...:..|:.|.|.. .:..:.|...| :|...:||.:.::.:                ..:|
Mouse   563 VTISSFLNSFVFKMIWD-GIVENAKGETL-ELFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKP 625

  Fly   561 KI---ELASKDRNIIAATFTH-----------FLLKNIGGSETFKDKQDFFYHEVRKFHASYYHE 611
            .:   || .|||........|           .|.:|:    ..|:|:.....|.........|
Mouse   626 GVLFQEL-DKDRRRAQLVLQHIPHVVPHKNRVLLFRNM----VIKEKEKLGLVETSSASPHVTH- 684

  Fly   612 KMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQG-----EQGIDWGGLRREWFELVCSALFD 671
               :.::|.::||...:.::..|.....|...|.|..     |.|||..|:.:|:.|.:...:||
Mouse   685 ---ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFD 746

  Fly   672 ARGGLFCTFHDKHQALVHPNPTRPAHLK-LKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSF 735
            ....||.|.....:  ::|:||...|.. |:.|||.|||:||.::|..       :|...|:..|
Mouse   747 PALNLFKTTSGDER--LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGI-------VVDVPFASFF 802

  Fly   736 LAQLIGLRVHYKYFEQD-------DPDLY--LSKIKYILDTDLDATDT-LELYFVEEMYDSSSGQ 790
            |:|::|  .|:..|...       |.:.|  |:.||..   |.|..|. |.|.:.|::    .||
Mouse   803 LSQMLG--HHHSVFYSSVDELPSLDSEFYKNLTSIKRY---DGDIADLGLTLSYDEDV----MGQ 858

  Fly   791 LSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENEL 855
            | ...||:|.|....||:..|..|:..:|..|:...:|::..:.:.|..|||....:.:|...||
Mouse   859 L-VCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPEL 922

  Fly   856 ELLMCG-TGEYSISDFKAHHIANGNSAEFRRVLAWFW-AGVSNFSQTEMARLLQFTTGCSQLPPG 918
            :.|:.| ..|..:.|.|.|.:..|......||:.|.| ...|:|:..|.|..|:|.|.||:.|..
Mouse   923 QRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLL 987

  Fly   919 GFQELNPQFQITAAPTF-------------------------GNLPTAHTCFNQLCLPDYESYEQ 958
            ||..|.|.|.|......                         |.|||:.||||.|.||:|.....
Mouse   988 GFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSV 1052

  Fly   959 FEKSLLLAISEGSEGF 974
            ..:.|..|||..: ||
Mouse  1053 LREKLRYAISMNT-GF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	118/403 (29%)
		HECTc	642..974	CDD:214523	111/374 (30%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	119/408 (29%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	112/377 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810