DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4238 and Magi2

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_446073.2 Gene:Magi2 / 113970 RGDID:621855 Length:1277 Species:Rattus norvegicus


Alignment Length:411 Identity:75/411 - (18%)
Similarity:133/411 - (32%) Gaps:146/411 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   676 LFCTFHDKH--QALVHPNPTRPAHLKLK-----HFEFAGKMV------GKCLF---ESALGGTYR 724
            ::.|::..|  :.....||...|..||:     |.|...|.:      .|.||   .|.|.||:.
  Rat   361 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFL 425

  Fly   725 QLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYIL-------DTDLDATDTLELYFVEE 782
            .....:.:..|...:||         .|:||.:| ::|.::       |..::..|.  :.::.|
  Rat   426 STTLKKSNMGFGFTIIG---------GDEPDEFL-QVKSVIPDGPAAQDGKMETGDV--IVYINE 478

  Fly   783 --MYDSSSGQLSKTIELIPNGAKTR---------------------------------VTNATKN 812
              :...:...:.|..:.:|.|....                                 :.|...|
  Rat   479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHN 543

  Fly   813 --QYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLS------IFDEN---------ELELLMC 860
              .||:.::  |...:|.|..|.....|:|:..|..|.      :.|:|         :.||:..
  Rat   544 YETYLEYIS--RTSQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSVASSGATQAELMTL 606

  Fly   861 -------GTGEYSISDFKAHH-------------IANGN-SAEFRRVLAWFWAGVSNFSQTEMAR 904
                   |.| ::|:|.....             :..|: ..|..:      ..|.|.|.||:..
  Rat   607 TIVKGAQGFG-FTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQ------QNVQNLSHTEVVD 664

  Fly   905 LLQFTTGCSQ----LPPGGF---------------QELNPQFQITAAPTFGNLPTAHTCFNQLCL 950
            :|:.....|:    :..|||               .:.:||..::|.....:||.. ...::...
  Rat   665 ILKDCPVGSETSLIIHRGGFFSPWKTPKPMVDRWENQGSPQTSLSAPAVPQSLPFP-PALHRSSF 728

  Fly   951 PDY---------ESYEQFEKS 962
            ||.         :.||.:|||
  Rat   729 PDSTEAFDPRKPDPYELYEKS 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720
Filamin 238..336 CDD:279024
HECTc 615..975 CDD:238033 75/411 (18%)
HECTc 642..974 CDD:214523 75/411 (18%)
Magi2NP_446073.2 PDZ_signaling 22..96 CDD:238492
GuKc 118..291 CDD:214504
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..308
Interaction with DDN. /evidence=ECO:0000250 302..381 4/19 (21%)
WW 304..333 CDD:395320
WW 350..381 CDD:197736 4/19 (21%)
PDZ 428..509 CDD:214570 14/92 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..575 5/18 (28%)
PDZ 602..683 CDD:214570 15/87 (17%)
MAGI_u5 687..758 CDD:406953 12/64 (19%)
PDZ 775..861 CDD:214570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..913
PDZ_signaling 920..1007 CDD:238492
PRK10263 <1007..>1135 CDD:236669
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1130
PDZ_signaling 1140..1220 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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