DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and WWP2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens

Alignment Length:	422	Identity:	133/422 - (31%)
Similarity:	201/422 - (47%)	Gaps:	59/422 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 TFKDKQDFF-------------------YHEVRKF-HASYYHEKMALKVQREKILESSMKAVKGF 633
            ||||.:..|                   ||:.|.. |::.....:.:.|.|:.:.|.|.:.:...
Human   471 TFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNM 535

  Fly   634 SVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFH--DKHQALVHPNPT--- 693
            ...|......:..:||:|:|:||:.||||.|:...:.:.   ::|.|.  .|:...:..||.
Human   536 KPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNP---MYCLFEYAGKNNYCLQINPASSI 597

  Fly   694 RPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYL 758
            .|.|  |.:|.|.|:.:...|:       :.:.:...|:..|..:::..|...|..|..||:.|
Human   598 NPDH--LTYFRFIGRFIAMALY-------HGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFY- 652

  Fly   759 SKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRL 823
            :.|.:|.:.:|:... |||||:::|  ...|::: |.||...|...|||...|.:|:..|...|.
Human   653 NSIVWIKENNLEECG-LELYFIQDM--EILGKVT-THELKEGGESIRVTEENKEEYIMLLTDWRF 713

  Fly   824 CNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFK-----AHHIANGNSAEF 883
            ...|:::..:||.|.|.:.|...|..|||.||||::||..|..:||::     .|:..|.
Human   714 TRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNS----- 773

  Fly   884 RRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQEL----NPQ-FQITAAPTFGNLPTAHT 943
             :.:.|||..|......:..|||||.||..:||.|||.||    .|| |.|........||.:||
Human   774 -KQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHT 837

  Fly   944 CFNQLCLPDYESYEQFEKSLLLAISEGSEGFG 975
            |||:|.||.|:||||..:.||.||.| :||||
Human   838 CFNRLDLPPYKSYEQLREKLLYAIEE-TEGFG 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	122/374 (33%)
		HECTc	642..974	CDD:214523	116/346 (34%)
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299
		Atrophin-1	<164..343	CDD:331285
		WW	302..331	CDD:306827
		WW	332..361	CDD:306827
		WW	407..435	CDD:306827
		WW	447..477	CDD:238122	4/5 (80%)
		HECTc	516..868	CDD:238033	122/375 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810