DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and Wwp1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_796301.2	Gene:	Wwp1 / 107568	MGIID:	1861728	Length:	918	Species:	Mus musculus

Alignment Length:	429	Identity:	133/429 - (31%)
Similarity:	205/429 - (47%)	Gaps:	45/429 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 DRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKF-----HASYYHEKMAL------KVQREK 621
            |.|....||..   ...|.|...|......|.  |.|     |..|..:..||      .|.|:.
Mouse   512 DHNTRTTTFKD---PRNGKSSVTKGGPQIAYE--RSFRWKLAHFRYLCQSNALPSHVKINVSRQT 571

  Fly   622 ILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFH--DKH 684
            :.|.|.:.:......|......|.|:||:|:|:|||.||||.|:...:.:.   ::|.|.  .|:
Mouse   572 LFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNP---MYCLFEYAGKN 633

  Fly   685 QALVHPNPT---RPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHY 746
            ...:..||.   .|.|  |.:|.|.|:.:...||       :.:.:...||..|..:::..::..
Mouse   634 NYCLQINPASTINPDH--LSYFCFIGRFIAMALF-------HGKFIDTGFSLPFYKRMLSKKLTI 689

  Fly   747 KYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATK 811
            |..|..|.:.|.|.| :|.|.:::... ||:||..:|  ...|::: :.:|...|:...||...|
Mouse   690 KDLESIDTEFYNSLI-WIRDNNIEECG-LEMYFSVDM--EILGKVT-SHDLKLGGSNILVTEENK 749

  Fly   812 NQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIA 876
            ::|:..:.:.|....|:::..:||.|.|.::|...|..|||.|||:::||..|..::|::.:.:.
Mouse   750 DEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVY 814

  Fly   877 NGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQEL----NPQ-FQITAAPTFG 936
            ...:...:::: |||..|.........|||||.||..:||.|||.||    .|| |.|.......
Mouse   815 RHYTRNSKQII-WFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT 878

  Fly   937 NLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFG 975
            .||.:|||||:|.||.|:||||.::.||.||.| :||||
Mouse   879 WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	118/375 (31%)
		HECTc	642..974	CDD:214523	111/341 (33%)
Wwp1	NP_796301.2	C2_E3_ubiquitin_ligase	17..140	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..182
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..360
		Interaction with ERBB4. /evidence=ECO:0000269\|PubMed:19561640	345..525		4/15 (27%)
		WW	347..376	CDD:278809
		WW	379..408	CDD:278809
		WW	454..483	CDD:278809
		WW	495..524	CDD:238122	4/14 (29%)
		HECTc	564..916	CDD:238033	117/370 (32%)
		HECTc	587..915	CDD:214523	112/346 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900