Protein Alignment CG4238 and Ube3c

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_598668.1
• Gene: Ube3c / 100763
• MGIID: 2140998
• Length: 1083
• Species: Mus musculus
• Alignment Length: 544
• Identity: 135/544 - (24%)
• Similarity: 225/544 - (41%)
• Gaps: 100/544 - (18%)

  Fly   488 GVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQ-------LVS 545
            ||:.|...:....:..|:...:|:|...  ::|.:..|......||..  |:|.:       .|:
Mouse   580 GVTTNSEMQQCIQMEQKRWVQLFKVITN--LVKMLKSRDTRRNFCPPN--HWLSEQEDIKADKVT 640

  Fly   546 QLH----------------GPVFIIDDGAQPKIEL--------ASKDRNIIAATFTHFLLKNIGG 586
            ||:                ||:       |..:|:        .|::|.:...|...|::.
Mouse   641 QLYVPASRHVWRFRRMGRIGPL-------QSTLEVGLESLPLSVSEERQLAILTELPFVVP---- 694

  Fly   587 SETFKDKQDFFYHEVRKFHASYYHEKMALK------------VQREKILESSMKAVKGFSVSDWC 639
                      |...|:.|....|.:|..::            ::|..|.|.:...:...:..|..
Mouse   695 ----------FEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLK 749

  Fly   640 GNFEVTFQG-----EQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLK 699
            ....|....     |.|||.||:.||:...:..:.|:...|.|.|   .::.|::|||.  |.:.
Mouse   750 KRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKT---TNEGLLYPNPA--AQML 809

  Fly   700 L-----KHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLR--VHYKYFEQDDPDLY 757
            :     :|:.|.|:|:||.|:|:       .||...|:..||::|:|..  |...:....||::|
Mouse   810 VGDSFARHYYFLGRMLGKALYEN-------MLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVY 867

  Fly   758 LSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQR 822
            .:.:  .|.:..:..:.|.|.|.....|....|:   :||...|....||.|.:..|:..:|..|
Mouse   868 RNLL--FLKSYEEDVEELGLNFTVVNNDLGEAQV---VELKFGGKDIPVTGANRIAYIHLVADYR 927

  Fly   823 LCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTG-EYSISDFKAHHIANGNSAEFRRV 886
            |...::....:|.:||.:::....|.:||:.|:::|:.|.. ..|:.|.|:....:|..:....|
Mouse   928 LNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHPV 992

  Fly   887 LAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQI-TAAPTFGNLPTAHTCFNQLCL 950
            :..||..|..|:..|..:||:|.|.||:.|..||:||.|.|.| ........||||.||.|.|.|
Mouse   993 IKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKL 1057

  Fly   951 PDYESYEQFEKSLLLAISEGSEGF 974
            |::.........||.|| |.:.||
Mouse  1058 PEFYDEALLRSKLLYAI-ECAAGF 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	107/386 (28%)
		HECTc	642..974	CDD:214523	101/345 (29%)
Ube3c	NP_598668.1	Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250	1..60
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..386
		HECTc	723..1081	CDD:238033	107/376 (28%)
		HECTc	747..1080	CDD:214523	102/350 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810