DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4238 and HUWE1

DIOPT Version :10

Sequence 1:NP_608640.2 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:XP_016884687.1 Gene:HUWE1 / 10075 HGNCID:30892 Length:4464 Species:Homo sapiens


Alignment Length:398 Identity:135/398 - (33%)
Similarity:211/398 - (53%) Gaps:29/398 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   590 FKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDW 654
            |..|:.:|..|:.:.......|.||:.|:|:.:.|.|.:.:...|..:......:.|:||:|.|.
Human  4084 FDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDA 4148

  Fly   655 GGLRREWFELVCSALFDARGGLFCTF-HDKHQALVHPNP-TRPAHLKLKHFEFAGKMVGKCLFES 717
            |||.|||:.::...:|:....||.|. .|:....::|:. ..|.|  |.:|:|.|::|.|.::::
Human  4149 GGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH--LSYFKFVGRIVAKAVYDN 4211

  Fly   718 ALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEE 782
                   :|:...|:|||...::|..|.|...|.:|...|...: |:|:.|: :|...:|.|..|
Human  4212 -------RLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLV-YLLENDV-STLGYDLTFSTE 4267

  Fly   783 MYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLL 847
            :.:..   :.:..:|.||||...||...|.:|:..:.|.|:...::.::.:||:|...|||..|:
Human  4268 VQEFG---VCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLI 4329

  Fly   848 SIFDENELELLMCGTGEYSISDFKA---HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFT 909
            |||.|.|||||:.|.....|.|.|:   :|....||.:    :.|||..:.:|.|.:.|:.|||.
Human  4330 SIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ----IQWFWRALRSFDQADRAKFLQFV 4390

  Fly   910 TGCSQLPPGGFQELN-----PQFQITAAP-TFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAIS 968
            ||.|::|..||..|.     .:|||.... :...||:||||||||.||.|||:|:....|||||.
Human  4391 TGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQ 4455

  Fly   969 EGSEGFGM 976
            |.|||||:
Human  4456 ECSEGFGL 4463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_608640.2 Filamin 238..336 CDD:395505
HECTc 615..975 CDD:238033 126/370 (34%)
HUWE1XP_016884687.1 DUF908 92..374 CDD:428721
DUF913 438..904 CDD:461803
UBA_HUWE1 1407..1446 CDD:270474
WWE 1707..1768 CDD:460715
PHA03247 <2825..3156 CDD:223021
UBM 3100..3133 CDD:464159
HECTc 4109..4462 CDD:238033 126/370 (34%)
Blue background indicates that the domain is not in the aligned region.

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