DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and HUWE1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_016884680.1	Gene:	HUWE1 / 10075	HGNCID:	30892	Length:	4501	Species:	Homo sapiens

Alignment Length:	398	Identity:	135/398 - (33%)
Similarity:	211/398 - (53%)	Gaps:	29/398 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 FKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDW 654
            |..|:.:|..|:.:.......|.||:.|:|:.:.|.|.:.:...|..:......:.|:||:|.|.
Human  4121 FDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDA 4185

  Fly   655 GGLRREWFELVCSALFDARGGLFCTF-HDKHQALVHPNP-TRPAHLKLKHFEFAGKMVGKCLFES 717
            |||.|||:.::...:|:....||.|. .|:....::|:. ..|.|  |.:|:|.|::|.|.::::
Human  4186 GGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH--LSYFKFVGRIVAKAVYDN 4248

  Fly   718 ALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEE 782
                   :|:...|:|||...::|..|.|...|.:|...|...: |:|:.|: :|...:|.|..|
Human  4249 -------RLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLV-YLLENDV-STLGYDLTFSTE 4304

  Fly   783 MYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLL 847
            :.:..   :.:..:|.||||...||...|.:|:..:.|.|:...::.::.:||:|...|||..|:
Human  4305 VQEFG---VCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLI 4366

  Fly   848 SIFDENELELLMCGTGEYSISDFKA---HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFT 909
            |||.|.|||||:.|.....|.|.|:   :|....||.:    :.|||..:.:|.|.:.|:.|||.
Human  4367 SIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ----IQWFWRALRSFDQADRAKFLQFV 4427

  Fly   910 TGCSQLPPGGFQELN-----PQFQITAAP-TFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAIS 968
            ||.|::|..||..|.     .:|||.... :...||:||||||||.||.|||:|:....|||||.
Human  4428 TGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQ 4492

  Fly   969 EGSEGFGM 976
            |.|||||:
Human  4493 ECSEGFGL 4500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	126/370 (34%)
		HECTc	642..974	CDD:214523	120/342 (35%)
HUWE1	XP_016884680.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820