DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and arel1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_002663081.2	Gene:	arel1 / 100332031	ZFINID:	ZDB-GENE-140106-259	Length:	1020	Species:	Danio rerio

Alignment Length:	1019	Identity:	445/1019 - (43%)
Similarity:	588/1019 - (57%)	Gaps:	151/1019 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 KLCFGESMGISSLSSCGDPERLPELPPLDEQRLQR----AALHLQQKLILREWLKDHRLQHHYQR 127
            |..|.:...:..||.| ...||.|:  :.|:|..|    |.:.|.:....:|||....|:|:|..
Zfish    45 KYLFEDVQTLEELSLC-VLSRLEEV--VKEKRHWREIIEAHVQLLRDFAFQEWLCSQSLEHYYHT 106

  Fly   128 LLAVEVASLEDV---------------YWLEDSRASKILGKDWQLWSGARQNLPTSKAQLDA-LK 176
            |..:...:|:|:               |:.||.         .:|.:|.|. |..||...|. .:
Zfish   107 LKTLGCTNLDDLAQFDSQLQLSLAAWGYYYEDY---------IKLSTGVRV-LQASKGSRDQDYE 161

  Fly   177 AQLWSTVVKSSQHQDAWTWGGMLV---------------------VSVSVAGLV-------TLAA 213
            .||..::.: .:..:.|::.|.|:                     ::||:...|       .|||
Zfish   162 VQLVHSLAE-RRLNEKWSFAGALIFGCTIALCFLIRDLMFYVIGGITVSIIAFVFTIKFLCELAA 225

  Fly   214 MTQPSLAPE--ARH---SLLQYVTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPI 273
            .....|..:  |||   |:..||.|.||.|.:|||.||||:|..||.||.|.|:.|.:||||:|.
Zfish   226 RVVSFLQNDDPARHGDRSIYDYVRGNYLDPRSCKVSWDWKEPQEVGQTMSFRVQLFYKNGQPFPA 290

  Fly   274 CDTDHFFVEVTEGTRKVVTISELGSST--------DPNNANIAKVKFTVRTAGQYKISVLIGASH 330
                |..|    |.|..:|..||....        :| .:|:.||.||||.||:|:::|.:|..:
Zfish   291 ----HRPV----GLRVNITHIELALEVPVTQEVLQEP-ESNVVKVAFTVRKAGRYEVAVKLGGLN 346

  Fly   331 IAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGY 395
            :|.||:.:.|.||.:...:::.....||::...|....:.||||||:||......:..||.  .|
Zfish   347 VAYSPYYKIFQPGTVVPSKTKIAYHFSTLVLTYGQQHTLQIEPRDEYGNPTSNSVSLVDEV--NY 409

  Fly   396 QVAIYDLHGVPVEKLQ--HAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVL 458
            .|.::.|..|..|..:  ::...:.:|...:|.:...|.:..|.||.||||||.|.||:||||||
Zfish   410 SVHVHPLGTVEEESSEDFYSTSVSANKPQCQVLMRLTFKKKGCFRACISYRDQPLRNGEFDIIVL 474

  Fly   459 SSSDTTLVHKNIASRKHNICYEAKLLS-----------------------------------IFG 488
            |.::...|.||:::...:|.:||.|.:                                   :.|
Zfish   475 SENEKNCVEKNVSTPGISIYFEAYLYNMGTYSSCPWQILASSQLALQRRPSMGEEEEEHDSPVEG 539

  Fly   489 VSK--NKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGP- 550
            .|:  .||:||.||:.|||.|      :||..||.||.|:.|||:||.|||.:        |||
Zfish   540 QSEKIRKPKKVYCYISPKQFS------VKEFYLKIIPWRLFTFRVCPGTKFTY--------HGPD 590

  Fly   551 ------VFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYY 609
                  ..::|||.||.:||:.|||||:||||..||.|||||||||:||.:||..|:|..|:...
Zfish   591 PVHKYLTLVVDDGIQPPVELSCKDRNIMAATFIRFLHKNIGGSETFQDKVNFFQRELRHIHSKRP 655

  Fly   610 HEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARG 674
            ..|.:||:.|..:||||:||.:.||||||..||||.||.|:.:||||.|||||||||.||||...
Zfish   656 RTKTSLKISRHSLLESSLKATRNFSVSDWSKNFEVVFQDEEALDWGGPRREWFELVCKALFDTNN 720

  Fly   675 GLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQL 739
            .||..|.|.:|.|||||..||.||::|.:||||::|||||:||||||:|:|||||||:||||||:
Zfish   721 QLFTRFSDNNQGLVHPNAERPPHLRVKMYEFAGRVVGKCLYESALGGSYKQLVRARFTRSFLAQI 785

  Fly   740 IGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKT 804
            ||||::|||||.||.:.|.:|:.:||:.|:...|   |.|.||.| |.||.|.|.:||||.||:.
Zfish   786 IGLRMNYKYFETDDEEFYKTKVCFILNNDVSEMD---LLFAEEKY-SKSGHLEKVVELIPGGAQI 846

  Fly   805 RVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISD 869
            .|||..||.||:.|||.||.:.|::||:.||||||.::|:|||:|||||||||||||||:.::.|
Zfish   847 AVTNENKNHYLNLLAQYRLASQVREEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVQD 911

  Fly   870 FKAHHIANGNSAEFR-RVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAP 933
            ||||.:..|.|..|| :|:.||||.||:|:|.|:|||||||||.||||||||..|.|.|||.|||
Zfish   912 FKAHAVIVGGSWHFREKVMKWFWAVVSSFTQEELARLLQFTTGSSQLPPGGFNTLCPSFQIIAAP 976

  Fly   934 TFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            |...||||||||||||||.|:|||:..|.|.||||||||||||:
Zfish   977 THSTLPTAHTCFNQLCLPTYDSYEELHKLLKLAISEGSEGFGML 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	43/105 (41%)
		Filamin	238..336	CDD:279024	43/105 (41%)
		HECTc	615..975	CDD:238033	230/360 (64%)
		HECTc	642..974	CDD:214523	213/332 (64%)
arel1	XP_002663081.2	SAM	29..89	CDD:197735	13/46 (28%)
		CobD_Cbib	167..>239	CDD:294379	11/72 (15%)
		Filamin	254..352	CDD:279024	43/106 (41%)
		HECTc	661..1018	CDD:238033	230/360 (64%)
		HECTc	683..1017	CDD:214523	216/337 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592809
Domainoid	1	1.000	406	1.000	Domainoid score	I676
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8885
Inparanoid	1	1.050	742	1.000	Inparanoid score	I575
OMA	1	1.010	-	-		QHG49700
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	1	1.000	-	-		FOG0008343
OrthoInspector	1	1.000	-	-		oto41313
orthoMCL	1	0.900	-	-		OOG6_108355
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4924
SonicParanoid	1	1.000	-	-		X6322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940