DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and hecw2a

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_009302976.1	Gene:	hecw2a / 100150269	ZFINID:	ZDB-GENE-090311-22	Length:	1475	Species:	Danio rerio

Alignment Length:	847	Identity:	205/847 - (24%)
Similarity:	353/847 - (41%)	Gaps:	172/847 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTMCFV-----VRFFQR-NGQPYPICDT-DH 278
            |..|..:.:|......||.|      |:......|.:.||     ...:|| .|.|.|...| ..
Zfish   709 PSVRQDIHRYQRVDEPLPPN------WEARIDSHGRIFFVDHVNRTTTWQRPTGPPAPQGLTRSS 767

  Fly   279 FFVEVTEGTRKVVTI-----SELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLR 338
            ..:::.:..|:..:|     ||........:....:.....::..:|:...:||.|.......|.
Zfish   768 SILQMEQLNRRYQSIRRTMTSERSEEPRVEDPPADETDVLAQSISEYRRDGIIGQSSSRSRLALL 832

  Fly   339 SFLPGAIDARRSRFIRPASTVICCAGAP---TLMHIEP---RDEFGNSCL-------------FD 384
            ...|||      :|:          .:|   :::|..|   |....|:||             |:
Zfish   833 LQSPGA------KFL----------SSPDFFSVLHSNPSAYRMFTSNTCLKHMISKVRRDAQHFE 881

  Fly   385 QNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLP 449
            :.|.:..|    |...:|......:|.......:|....     |.|.:..| ||. ::.|.:||
Zfish   882 RYQHNRDL----VNFLNLFSNKQLELPRGWEMKHDHTGK-----AFFVDHNC-RAT-TFIDPRLP 935

  Fly   450 NGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQ--- 511
                  :..|.|...|.|:...||:.:  :.|..:.....|.:.|.:     |....:..:|
Zfish   936 ------LQNSRSSGLLAHRQHLSRQRS--HSAGEVGDDSRSPSPPVQ-----GRSSRNSQYQDLV 987

  Fly   512 -VTIKEMILKFIPKRIATFRLCPSTKFHFLPQLV--SQLHGPV-FIIDDGAQPKIELASKDRNII 572
             |...:.|:.|: ::...|.:....:    |:||  ..|...| ||.::||.....|:| |.:::
Zfish   988 PVAYNDKIVAFL-RQPNIFEILQERQ----PELVRNHSLREKVQFIRNEGATGLTRLSS-DADLV 1046

  Fly   573 --------------------AATFTHFLLKNIGGSETFKD------KQDF------FYHEVRKFH 605
                                .:::.|...::..|:.....      |:||      ||   ||..
Zfish  1047 MLLSLFEEEVMSYVPPNALLLSSYCHASPQSSPGTPRANARAPAPYKRDFEAKLRNFY---RKME 1108

  Fly   606 ASYYHE---KMALKVQREKILESSMKAVKGFSVSD-WCGNFEVTFQGEQGIDWGGLRREWFELVC 666
            ...|.:   |:.|.::|:.:||.:...:..:|..| ......|:|.||:|:|:.|..||:|.||.
Zfish  1109 TKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSRLYVSFVGEEGLDYSGPSREFFFLVS 1173

  Fly   667 SALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKLKH--FEFAGKMVGKCLFESALGGTYRQLVR 728
            ..||:...||| .:.:|.:...:.|   ..|.:...|  |.|:|:::|..|.       ::.|:.
Zfish  1174 RELFNPYYGLFEYSANDTYTVQISP---MSAFVDNHHEWFRFSGRILGLALI-------HQYLLD 1228

  Fly   729 ARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFV--EEMYDSSSGQL 791
            |.|:|.|...|:.:.......|..|.:.:.| ::::.|.|::  |.|:|.|.  ||::    ||:
Zfish  1229 AFFTRPFYKGLLRIPCDLSDLEFLDEEFHQS-LQWMKDNDIE--DMLDLTFTVNEEVF----GQI 1286

  Fly   792 SKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELE 856
            ::. ||.|.|:...|::..|.:|::.:.:.|:...|..:.:|.::|...::...|:|:||..|||
Zfish  1287 TER-ELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELE 1350

  Fly   857 LLMCGTGEYSISDFKAHHIANGNSAEFRR-------VLAWFWAGVSNFSQTEMARLLQFTTGCSQ 914
            |::.||.|..:||::       |:.|:|.       |:.||||.|..|:..:..|||||.||.|.
Zfish  1351 LVIAGTAEIDLSDWR-------NNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSS 1408

  Fly   915 LPPGGFQELN-----PQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            :|..||..|.     .:|.:.......:||.||||||:|.||.|.|:....:.::.|:.|.|. |
Zfish  1409 IPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETST-F 1472

  Fly   975 GM 976
            |:
Zfish  1473 GL 1474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	20/109 (18%)
		Filamin	238..336	CDD:279024	20/109 (18%)
		HECTc	615..975	CDD:238033	114/377 (30%)
		HECTc	642..974	CDD:214523	108/348 (31%)
hecw2a	XP_009302976.1	HECW_N	50..169	CDD:318711
		C2_NEDL1-like	188..323	CDD:176073
		WW	724..756	CDD:197736	9/37 (24%)
		WW	903..934	CDD:197736	8/37 (22%)
		HECTc	1120..1473	CDD:238033	114/378 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810