DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and huwe1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_031748028.1	Gene:	huwe1 / 100126217	XenbaseID:	XB-GENE-957703	Length:	4380	Species:	Xenopus tropicalis

Alignment Length:	398	Identity:	135/398 - (33%)
Similarity:	211/398 - (53%)	Gaps:	29/398 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 FKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDW 654
            |..|:.:|..|:.:.......|.||:.|:|:.:.|.|.:.:...|..:......:.|:||:|.|.
Frog  4000 FDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDA 4064

  Fly   655 GGLRREWFELVCSALFDARGGLFCTF-HDKHQALVHPNP-TRPAHLKLKHFEFAGKMVGKCLFES 717
            |||.|||:.::...:|:....||.|. .|:....::|:. ..|.|  |.:|:|.|::|.|.::::
Frog  4065 GGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH--LSYFKFVGRIVAKAVYDN 4127

  Fly   718 ALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEE 782
                   :|:...|:|||...::|..|.|...|.:|...|...: |:|:.|: :|...:|.|..|
Frog  4128 -------RLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLV-YLLENDV-STLGYDLTFSTE 4183

  Fly   783 MYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLL 847
            :.:..   :.:..:|.||||...||...|.:|:..:.|.::...::.::.:||:|...|||..|:
Frog  4184 VQEFG---VCEVRDLKPNGANILVTEENKKEYVHLVCQMKMTGAIRKQLAAFLEGFYEIIPKRLI 4245

  Fly   848 SIFDENELELLMCGTGEYSISDFKA---HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFT 909
            |||.|.|||||:.|.....|.|.|:   :|....||.:    :.|||..:.:|.|.:.|:.|||.
Frog  4246 SIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ----IQWFWRALRSFDQADRAKFLQFV 4306

  Fly   910 TGCSQLPPGGFQELN-----PQFQITAAP-TFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAIS 968
            ||.|::|..||..|.     .:|||.... :...||:||||||||.||.|||||:....|||||.
Frog  4307 TGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQ 4371

  Fly   969 EGSEGFGM 976
            |.|||||:
Frog  4372 ECSEGFGL 4379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	126/370 (34%)
		HECTc	642..974	CDD:214523	120/342 (35%)
huwe1	XP_031748028.1	DUF908	90..367	CDD:399185
		DUF913	431..859	CDD:399192
		UBA_HUWE1	<1371..1401	CDD:270474
		WWE	1662..1723	CDD:397111
		PHA03247	<2760..3100	CDD:223021
		HECTc	4025..4378	CDD:238033	126/370 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010