DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and herc3

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001139096.1	Gene:	herc3 / 100003587	ZFINID:	ZDB-GENE-090313-139	Length:	1046	Species:	Danio rerio

Alignment Length:	382	Identity:	88/382 - (23%)
Similarity:	159/382 - (41%)	Gaps:	51/382 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 MALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF 677
            :.|.|:|..::..:::.:..::..|.....:|.|.||:.:|.||:.:|:|.|:...|.:...|:|
Zfish   699 LVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMF 763

  Fly   678 CTFHDKH------QALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFL 736
            ..:.:.:      :..|..|          .|...|.:.|..::.|.:...:..||.
Zfish   764 TQYSESNLLWFSDKCFVEHN----------WFHLIGIICGLAIYNSTVVDLHFPLVL-------- 810

  Fly   737 AQLIGLRVHYKYFEQDDPDL----YLS-----KIKYILDTDLDATDTLELYF--VEEMYDSSSGQ 790
                     ||...:..|.|    .||     .::.:|:.:.|..:|..|.|  ..|.|.
Zfish   811 ---------YKKLLEISPTLDDLKELSPTEGRSLQQLLEFEGDVEETFCLNFAITREYYG----- 861

  Fly   791 LSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENEL 855
            :::..||:..|....|....:.:::.|..|....:.|:::..:|..|...:....:||:|..:||
Zfish   862 ITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSEL 926

  Fly   856 ELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGF 920
            ..::.|...|:..:.:.:....|..:.....:..||.....||..:..:.|.|.||..::|..|.
Zfish   927 MAMVVGNNNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGM 991

  Fly   921 QELNPQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            ..|....|.|||... .||.||||:|.|.:|.|::.|...:.|..|: |..|||.:|
Zfish   992 ASLRIVIQSTAAEEH-YLPVAHTCYNMLDMPCYQTKETLRQRLTQAV-EQYEGFSLV 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	86/376 (23%)
		HECTc	642..974	CDD:214523	81/348 (23%)
herc3	NP_001139096.1	RCC1	4..49	CDD:278826
		RCC1_2	37..65	CDD:290274
		RCC1	52..99	CDD:278826
		RCC1	103..152	CDD:278826
		RCC1	155..205	CDD:278826
		RCC1	208..257	CDD:278826
		RCC1	260..308	CDD:278826
		RCC1	314..374	CDD:278826
		HECTc	699..1044	CDD:238033	86/378 (23%)
		HECTc	723..1043	CDD:214523	82/353 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810