DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Got2 and got-2.2

DIOPT Version :9

Sequence 1:	NP_722745.1	Gene:	Got2 / 33373	FlyBaseID:	FBgn0001125	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_741810.1	Gene:	got-2.2 / 180897	WormBaseID:	WBGene00015778	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	405	Identity:	266/405 - (65%)
Similarity:	327/405 - (80%)	Gaps:	1/405 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ANRVSTWFSEVQMGPPDAILGVTEAFKKDTNPKKINLGAGAYRDDNTQPFVLPSVREAEKRVVSR 91
            |.|..:|:|.|:|||||||||||||||.|:||||||||.||||||..:|||||||:|||::|::.
Worm    11 AVRGKSWWSHVEMGPPDAILGVTEAFKADSNPKKINLGVGAYRDDQGKPFVLPSVKEAERQVIAA 75

  Fly    92 SLDKEYATIIGIPEFYNKAIELALGKGSKRLAAKHNVTAQSISGTGALRIGAAFLAKFWQGNREI 156
            :||||||.|:|:|||...:.:||||:.|..:..|...|.||||||||||||:.||:|:.: .:.|
Worm    76 NLDKEYAGIVGLPEFTKLSAQLALGENSDVIKNKRIFTTQSISGTGALRIGSEFLSKYAK-TKVI 139

  Fly   157 YIPSPSWGNHVAIFEHAGLPVNRYRYYDKDTCALDFGGLIEDLKKIPEKSIVLLHACAHNPTGVD 221
            |.|:|:|||||.||:.||:.|.:||||||.||..|..|.:.|:.:|||.|.:|||||||||||||
Worm   140 YQPTPTWGNHVPIFKFAGVDVKQYRYYDKSTCGFDETGALADIAQIPEGSTILLHACAHNPTGVD 204

  Fly   222 PTLEQWREISALVKKRNLYPFIDMAYQGFATGDIDRDAQAVRTFEADGHDFCLAQSFAKNMGLYG 286
            |:.:||::||.:||||||:.|.||||||||:||:|.||.|||.|...||:..|:|||||||||||
Worm   205 PSRDQWKKISDIVKKRNLFVFFDMAYQGFASGDVDNDAFAVRYFVEQGHNIVLSQSFAKNMGLYG 269

  Fly   287 ERAGAFTVLCSDEEEAARVMSQVKILIRGLYSNPPVHGARIAAEILNNEDLRAQWLKDVKLMADR 351
            ||.|||:|:.||.:|||||.||||||||.|||||||||||||:.||.:..|..|||.||||||||
Worm   270 ERVGAFSVVTSDADEAARVASQVKILIRPLYSNPPVHGARIASRILADPALNKQWLGDVKLMADR 334

  Fly   352 IIDVRTKLKDNLIKLGSSQNWDHIVNQIGMFCFTGLKPEQVQKLIKDHSVYLTNDGRVSMAGVTS 416
            ||.:||.|||.|.|.||::||:||.||||||||||:.|:||:||||:||||||.|||:|:||::|
Worm   335 IITMRTTLKDLLAKEGSTRNWEHITNQIGMFCFTGINPQQVEKLIKEHSVYLTKDGRISVAGISS 399

  Fly   417 KNVEYLAESIHKVTK 431
            .||.|||.::|:|||
Worm   400 NNVAYLAHALHQVTK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Got2	NP_722745.1	AAT_I	21..431	CDD:302748	264/403 (66%)
Got2	NP_722745.1	Aminotran_1_2	58..426	CDD:278580	240/367 (65%)
got-2.2	NP_741810.1	AAT_I	1..414	CDD:302748	264/403 (66%)
got-2.2	NP_741810.1	Aminotran_1_2	42..409	CDD:278580	240/367 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157485
Domainoid	1	1.000	489	1.000	Domainoid score	I186
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1572
Inparanoid	1	1.050	545	1.000	Inparanoid score	I626
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62835
OrthoDB	1	1.010	-	-		D1104596at2759
OrthoFinder	1	1.000	-	-		FOG0000707
OrthoInspector	1	1.000	-	-		otm14192
orthoMCL	1	0.900	-	-		OOG6_100337
Panther	1	1.100	-	-	LDO	PTHR11879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X428
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910