DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7289 and KIAA2013

DIOPT Version :9

Sequence 1:	NP_608635.1	Gene:	CG7289 / 33372	FlyBaseID:	FBgn0031379	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_612355.1	Gene:	KIAA2013 / 90231	HGNCID:	28513	Length:	634	Species:	Homo sapiens

Alignment Length:	584	Identity:	165/584 - (28%)
Similarity:	273/584 - (46%)	Gaps:	113/584 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 PGER------DFTPYVGNGYL-GLEIAHDAFLNIKNG-----RAMQL------PIPFQPVVSVSG 142
            ||||      ||.|:|....| .|..|.:|.|.::.|     |.:||      |:...|..:...
Human   111 PGEREPAVAPDFVPFVQLRPLSALAEAGEAVLLLREGLLRRVRCLQLGSPGPGPVAAGPGPASVS 175

  Fly   143 GSASGGEKEATVVEYLTGMVHRFQCFAGYFVSYTYYAHRTQPNIFMQELQITNTRNLLEDIELIM 207
            |.|:|..::..:::                  ..:.|||.:|::::|.:|:.|....:..::.:.
Human   176 GLAAGSGRDCVLLQ------------------EDFLAHRGRPHVYLQRIQLNNPTERVAALQTVG 222

  Fly   208 PRV---------NLQKLTRRTVPL----SEPVSVGVFTYTELEVLSGTVQLQAENPSKSIVISIV 259
            |..         .|:|:......|    |.|...|:   ..|.|::          :|.:|..:
Human   223 PTAGPAPKAFTSTLEKVGDHQFLLYSGRSPPTPTGL---VHLVVVA----------AKKLVNRL- 273

  Fly   260 KPQMDSKLQLRKRGTVRIVYPTAVHYSKP----VAEEKIGGISETIEQQATQAMAKLLQKLGSKP 320
              |:..|.||.:  ||..|    ||.|.|    |.:.|.....:.::..|.:.|.:||....::
Human   274 --QVAPKTQLDE--TVLWV----VHVSGPINPQVLKSKAAKELKALQDLARKEMLELLDMPAAE- 329

  Fly   321 SNPGSLNSVNIYRQEHIDVWTDLWATGFTISTSKAENSLNGDRINATMYAVLS------QVRSFE 379
                       ..|:|..:|..|::.|..:......::.:|..:|.|:|.:||      ...|..
Human   330 -----------LLQDHQLLWAQLFSPGVEMKKITDTHTPSGLTVNLTLYYMLSCSPAPLLSPSLS 383

  Fly   380 FEEAGGSKKEDIAKALTYAEGCYDSYHTLQAENLW-REMSNLQQLNSLVTSWMLTLEKQGCHNLI 443
            ..|     ::.:...|.|.:.|:..:.|:.||||| ..:|::||:..|...|.|||:|:||..|:
Human   384 HRE-----RDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLSDLWRLTLQKRGCKGLV 443

  Fly   444 RAGASGVIQAMVLSFGSFRFSNQHLECNIHPKFLHRDFHFRRLNYGNKTHVNVTIIVDDDNKAVI 508
            :.||.|::|.||||||..:|:..||:....|..||..:....:.|.| .|:|:.::.|.:.|..:
Human   444 KVGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKN-DHINLAVLADAEGKPYL 507

  Fly   509 NIALDRSDR--SYYACDGGCLDEPVLLTQ--NRRQFPVKLTEPLTAILYITEDKQHMEELHHAIH 569
            :::::...:  ..|||..|||||||.||.  ....|.|.:|:|:|.:|||:.|..|:::|.|.:|
Human   508 HVSVESRGQPVKIYACKAGCLDEPVELTSAPTGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLH 572

  Fly   570 VKEVVEAPAHEQHLIALHRHGHQLGGLPTLFWVSVCAIIIVFHIFLCKLIIKEYCEPSDKLRYR 633
            :|.::   ||::|:      ..|..|||.|||.||.::|.:||:||.|||..|||.|..|..:|
Human   573 LKAIL---AHDEHM------AQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFR 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7289	NP_608635.1	DUF2152	18..635	CDD:287225	165/584 (28%)
KIAA2013	NP_612355.1	DUF2152	6..629	CDD:287225	165/584 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152609
Domainoid	1	1.000	214	1.000	Domainoid score	I2746
eggNOG	1	0.900	-	-		E1_KOG3778
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12668
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3637
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378033at33208
OrthoFinder	1	1.000	-	-		FOG0006028
OrthoInspector	1	1.000	-	-		oto90097
orthoMCL	1	0.900	-	-		OOG6_107711
Panther	1	1.100	-	-	LDO	PTHR31386
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3545
SonicParanoid	1	1.000	-	-		X4325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790