DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15356 and EMSY

DIOPT Version :9

Sequence 1:	NP_608633.1	Gene:	CG15356 / 33370	FlyBaseID:	FBgn0031377	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_011543475.1	Gene:	EMSY / 56946	HGNCID:	18071	Length:	1353	Species:	Homo sapiens

Alignment Length:	1144	Identity:	284/1144 - (24%)
Similarity:	427/1144 - (37%)	Gaps:	354/1144 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWPQTLEMSRDECRGMLRRLELESYSHVVSVFRAQGALSETKAKLLEELRQQFHINQERHRAEVR 65
            :||..|::|||||:.:||:||||:|:.|:|..||||.|::.|..||.||.:...|:.||||||||
Human     4 VWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVR 68

  Fly    66 RAANDEQLCTIAE--------------NVCGPNTWQEWSREGRRLYPLLPRISPQTALSIVANDL 116
            ||.|||:|.|||.              ::.|||:..|||.|||||.||:||:.||||.::.||.:
Human    69 RAVNDERLTTIAHKMNLSLYLGERPSYSMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAV 133

  Fly   117 AAKACEENAKLAAPAET-----AVHFG---------EALVEQASLMSLKYPRGARIQDTAMVIMA 167
            |..|.:.||.|..||||     .|.:.         ...|...|:.::|.||.|......:|
Human   134 ANAAIQHNASLPVPAETGSKEVVVCYSYTSTTSTPTSTPVPSGSIATVKSPRPASPASNVVV--- 195

  Fly   168 EPFKVPDLPNEVKKMTQKRKENDSGIDGKPNKKRHMQQPHPQQPHLQASQQQQQSQQLNPNSSNP 232
                   ||:......:....:|.  |.||.|:|                      :.|.:||:|
Human   196 -------LPSGSTVYVKSVSCSDE--DEKPRKRR----------------------RTNSSSSSP 229

  Fly   233 GMEEADP---VPPEKRMTARTLQQRYFYQQQMKHKQRLAS-KRNLANRL-----------GSPSA 282
            .:.:..|   ||..|.:|.           .:....:::: .:::||.|           ..||.
Human   230 VVLKEVPKAVVPVSKTITV-----------PVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPST 283

  Fly   283 QSGNPLGGRNMPSSGGDTSTAKRSAAPAKSGRRAQKQLQQQQKLQQHQQQKVLM----QSQETVP 343
            |:.|             |:|                             |||::    .|...||
Human   284 QTTN-------------TTT-----------------------------QKVIIVTTSPSSTFVP 306

  Fly   344 NHMVVQPHVEYVLDEALKTLAASNPPTPTSTVAPPYTILNEPRPLVTLKPLKTIKPMIYGPQSGM 408
            |          :|.:: ...||.....|||.:|   :...:|..::|......:.....|..|..
Human   307 N----------ILSKS-HNYAAVTKLVPTSVIA---STTQKPPVVITASQSSLVSNSSSGSSSST 357

  Fly   409 PSAEIGSPTTPGSRGFANSPIVFKEKLQASP-VQVATQGQGSPTKKFVAEERHADAMPSAATTPT 472
            ||.   .|.|          :.....:.::| |.::|..||..|...........:..|..:.||
Human   358 PSP---IPNT----------VAVTAVVSSTPSVVMSTVAQGVSTSAIKMASTRLPSPKSLVSAPT 409

  Fly   473 PISTANLPLAPQIISVQKIPAPSMGGKLRAAVASPTS---STNSTLLPPGAKTT-----PKKFNI 529
            .| .|..|...|....|::.......:.:.|..||.|   ....:.||||.|.|     .....|
Human   410 QI-LAQFPKQHQQSPKQQLYQVQQQTQQQVAQPSPVSHQQQPQQSPLPPGIKPTIQIKQESGVKI 473

  Fly   530 LEGDAKPKTLPSSAVRLLPYTEPIGGPLSPLKDSRVTPLSSASTVNIIKNIPASSLNNTLITPLP 594
            :....:|.       ::||  :|:...|         |.||.|.:.::     ||....:.|.|.
Human   474 ITQQVQPS-------KILP--KPVTATL---------PTSSNSPIMVV-----SSNGAIMTTKLV 515

  Fly   595 SAGTTMPANLFRAKVTPSIKGASGAAGGATVIGAAGATGIGGAGAGPQILGNIKLTSSSGGAATI 659
            :..|...|...|..|:|||...:...|.||.                     :|.||.|    .|
Human   516 TTPTGTQATYTRPTVSPSIGRMAATPGAATY---------------------VKTTSGS----II 555

  Fly   660 KQVPSSALRNIKICSPNGKLFLQPGKLPAGSIIHKFNNASSTAVSAAGGVVTTTTTTVSPTKQPA 724
            ..||.|      :.:..||:.                  ||..||.    .||..||:..|.:|
Human   556 TVVPKS------LATLGGKII------------------SSNIVSG----TTTKITTIPMTSKP- 591

  Fly   725 REQRISIQKILQPATGSASSGSSSPTTTTTTISGLTSSAKQPGLGNKPTTLTFATAGGGKNNLVF 789
              ..|.:||    .||..           |||.||      || .|..|||..|   ||:..:..
Human   592 --NVIVVQK----TTGKG-----------TTIQGL------PG-KNVVTTLLNA---GGEKTIQT 629

  Fly   790 LPASAASGMRALTLATKPKSNVLV-----IGASTSPASAASSP-----NPSGGT----KPK---- 836
            :|..|..   |:..||:|.:.::|     ||::..|| |...|     ...|.|    |||
Human   630 VPTGAKP---AILTATRPITKMIVTQPKGIGSTVQPA-AKIIPTKIVYGQQGKTQVLIKPKPVTF 690

  Fly   837 --------ANQLITEDTPIDIINMPIIVADNG-------------------TAAELNQASVKNSP 874
                    ..||:||     .:.....||:.|                   ::.|.:|:|..:.|
Human   691 QATVVSEQTRQLVTE-----TLQQASRVAEAGNSSIQEGKEEPQNYTDSSSSSTESSQSSQDSQP 750

  Fly   875 LVVFNAT---DW---EMELDQAAT---KSASTTSKQALDDV--IIEEDEDAEEEARESSEQPSTM 928
            :|...|:   ||   |:.::.:.|   :..|:.|:.|...:  ::|..:...:|..||..:..|:
Human   751 VVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLESKPRQPTI 815

  Fly   929 DLNNSIIEL-------HPEDDSAIEYVDMDLEQPVEIESTSNISPETATTTLKAAIVS---TSPQ 983
            ||:...:.:       |..:..:|..|:.:|.........::...|.|...|.|.::|   :||.
Human   816 DLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTERTDEGTEVAFPLLDAVVISGEISSPP 880

  Fly   984 ----QQQQQPQKKHPPLEHPLSAGAAAGTGSSTGAAVQS 1018
                ..:.|||:...|....|...|.:.|.:.|...|:|
Human   881 LFSVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKS 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15356	NP_608633.1	ENT	16..82	CDD:281696	37/79 (47%)
EMSY	XP_011543475.1	ENT	19..81	CDD:397688	36/61 (59%)
EMSY	XP_011543475.1	Atrophin-1	<974..>1174	CDD:397323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148790
Domainoid	1	1.000	79	1.000	Domainoid score	I8729
eggNOG	1	0.900	-	-		E1_KOG4675
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4271
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008212
OrthoInspector	1	1.000	-	-		oto88799
orthoMCL	1	0.900	-	-		OOG6_109408
Panther	1	1.100	-	-	LDO	PTHR16500
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.840